Evidence map›Paper›PMID 36747781›Full record

ArticleResearch square2023

RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice.

Sabrina Villar-Pazos, Laurel Thomas, Yunhan Yang, Kun Chen, Jenea B Lyles, Bradley J Deitch, Joseph Ochaba, Karen Ling, Berit Powers, Sebastien Gingras and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Sabrina Villar-PazosDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Laurel ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Yunhan YangDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Kun ChenDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Jenea B LylesDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Bradley J DeitchDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Joseph OchabaIonis Pharmaceuticals, Carlsbad, CA, USA.
Karen LingIonis Pharmaceuticals, Carlsbad, CA, USA.
Berit PowersIonis Pharmaceuticals, Carlsbad, CA, USA.
Sebastien GingrasDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.ORCID 0000-0003-2607-8642
Holly B KordasiewiczIonis Pharmaceuticals, Carlsbad, CA, USA.
Melanie J GrubishaDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yanhua H HuangDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-1770-0196
Gary ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
University of Pittsburgh · USIonis Pharmaceuticals (United States) · US

Funding

Molecular, Cellular and Behavioral Impact of the R203W PACS1 Syndrome MutationR01NS123649 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGELA M. GRONENBORN, Gary Thomas · 2022 to 2026
$3.3M
Allosteric regulation of SIRT1 by a PACS-2 and DBC1 regulatory hubR01DK114855 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M., THOMAS, GARY · 2017 to 2020
$2.4M
Regulation of PPAR alpha by PACS-2 in response to nutrient stressR01DK112844 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMAS, GARY · 2017 to 2019
$1.2M
NIDDK NIH HHS R01 DK112844NIDDK NIH HHS R01 DK114855NINDS NIH HHS R01 NS123649
6 · The paper itself

Abstract

Neurodevelopmental disorders (NDDs) are frequently associated with dendritic abnormalities in pyramidal neurons that affect arbor complexity, spine density, and synaptic communication

Identifiers

PMID36747781
PMCPMC9901029
OpenAlexW4318309091

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.