Evidence map›Paper›PMID 36747766›Full record

ArticlebioRxiv : the preprint server for biology2023

Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease.

Lola Holcomb, Johanna M Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M Mawe and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Lola HolcombGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA 04469.
Johanna M HolmanSchool of Food and Agriculture, University of Maine, Orono, Maine, USA 04469.
Molly HurdLarner College of Medicine, University of Vermont, Burlington, Vermont, USA 05401.
Brigitte LavoieLarner College of Medicine, University of Vermont, Burlington, Vermont, USA 05401.
Louisa ColucciDepartment of Biology, Husson University, Bangor, Maine, USA 04401.
Benjamin HuntDepartment of Biology, University of Maine, Orono, Maine, USA 04469.
Timothy HuntDepartment of Biology, University of Maine, Orono, Maine, USA 04469.
Marissa KinneySchool of Food and Agriculture, University of Maine, Orono, Maine, USA 04469.
Jahnavi PathakGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA 04469.
Gary M MaweLarner College of Medicine, University of Vermont, Burlington, Vermont, USA 05401.
Peter L MosesLarner College of Medicine, University of Vermont, Burlington, Vermont, USA 05401.
Emma PerryElectron Microscopy Laboratory, University of Maine, Orono, Maine, USA 04469.
Allesandra StratigakisSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA 13790.
Tao ZhangSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA 13790.
Grace ChenDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA 48109.
Suzanne L IshaqGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA 04469.
Yanyan LiGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA 04469.
University of Maine · USUniversity of Vermont · USBinghamton University · USHusson University · USUniversity of Michigan · US

Funding

Harnessing gut microbiota to reduce inflammation using broccoli-sprout dietsR15DK133826 · NIDDK · UNIVERSITY OF MAINE ORONO · PI PELLEGRINI, SUZANNE ISHAQ · 2022 to 2022
$436k
NIDDK NIH HHS R15 DK133826
6 · The paper itself

Abstract

Crohn's Disease (CD) is a presentation of Inflammatory Bowel Disease (IBD) that manifests in childhood and adolescence, and involves chronic and severe enterocolitis, immune and gut microbiome dysregulation, and other complications. Diet and gut-microbiota-produced metabolites are sources of anti-inflammatories which could ameliorate symptoms. However, questions remain on how IBD influences biogeographic patterns of microbial location and function in the gut, how early life transitional gut communities are affected by IBD and diet interventions, and how disruption to biogeography alters disease mediation by diet components or microbial metabolites. Many studies on diet and IBD use a chemically induced ulcerative colitis model, despite the availability of an immune-modulated CD model. Interleukin-10-knockout (IL-10-KO) mice on a C57BL/6 background, beginning at age 4 or 7 weeks, were fed a control diet or one containing 10% (w/w) raw broccoli sprouts, which was high in the sprout-sourced anti-inflammatory sulforaphane. Diets began 7 days prior to, and for 2 weeks after inoculation with

Indexed as

16S rDNACrohn’s Diseasecruciferous vegetablesdietary bioactivesglucoraphaningut microbiotainterleukin-10 knockoutsulforaphane

Identifiers

PMID36747766
PMCPMC9900910
OpenAlexW4318397867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.