ArticlebioRxiv : the preprint server for biology2023
Hyperextended telomeres promote C-circle formation in telomerase positive human cells.
Celina Y Jones, Christopher L Williams, Sara P Moreno, Danna K Morris, Chiara Mondello, Jan Karlseder, Alison A Bertuch
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors at 3 institutions in 2 countries.
Celina Y JonesDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Christopher L WilliamsDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Sara P MorenoMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Danna K MorrisDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Chiara MondelloInstitute of Molecular Genetics, Luigi Luca Cavalli Sforza, National Research Council, Pavia, Italy I-27100.
Jan KarlsederMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Alison A BertuchDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · USSalk Institute for Biological Studies · USIstituto di Genetica Molecolare · IT
Funding
Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6MPROGRAM IN HUMAN MOLECULAR GENETICST32GM008307 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SHAULSKY, GAD · 1990 to 2020
$6.6MUnderstanding the role of autophagy-regulated cell death in the escape from replicative crisisR01CA234047 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KARLSEDER, JAN, SHAW, REUBEN · 2020 to 2024
$3.1MA nucleus-to-mitochondria nucleic acid-sensing pathway prevents bypass of age-associated proliferative boundariesR01AG077324 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Jan Karlseder · 2022 to 2026
$3.0MMitochondria-to-Nucleus Signaling in Colorectal CancerR01CA228211 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, SHADEL, GERALD · 2020 to 2024
$2.6MUnderstanding DNA break repair pathway choice regulation by the cNHEJ inhibitor CYRENR01CA227934 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KARLSEDER, JAN · 2018 to 2022
$2.2MTHE ROLE OF TELOMERASE REGULATORS IN TELOMERE MAINTENANCE AND GENOMIC INSTABILITYR01CA211653 · NCI · BAYLOR COLLEGE OF MEDICINE · PI BERTUCH, ALISON A · 2017 to 2022
$1.8MNCI NIH HHS R01 CA211653NCI NIH HHS R01 CA227934NCI NIH HHS R01 CA228211NCI NIH HHS R01 CA234047NIA NIH HHS R01 AG077324NIGMS NIH HHS T32 GM007750NIGMS NIH HHS T32 GM008307
6 · The paper itselfAbstract
Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs). How C-circles form is not well characterized. To investigate C-circle formation in telomerase+ cells, we studied the human cen3tel cell line, in which telomeres progressively hyper-elongated post
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PMID36747763
PMCPMC9900909
OpenAlexW4318294164
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