Evidence map›Paper›PMID 36747743›Full record

ArticlebioRxiv : the preprint server for biology2023

Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.

Yanan Chen, Songhua Quan, Vaibhav Patil, Rejani B Kunjamma, Haley M Tokars, Eric D Leisten, Jonah Chan, Yvette Wong, Brian Popko

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yanan ChenDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Songhua QuanDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Vaibhav PatilDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Rejani B KunjammaDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Haley M TokarsDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Eric D LeistenDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Jonah ChanWeill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Yvette WongDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Brian PopkoDepartment of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · USUniversity of California, San Francisco · US

Funding

Targeting the integrated stress response to protect oligodendrocyte lineage cells - Resubmission 01R01NS034939 · NINDS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKO, BRIAN J · 1997 to 2024
$7.5M
NINDS NIH HHS R01 NS034939
6 · The paper itself

Abstract

CNS inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging the ISR protects remyelinating oligodendrocytes and promotes remyelination in the presence of inflammation (Chen et al.,

Identifiers

PMID36747743
PMCPMC9900777
OpenAlexW4317815475

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.