Evidence map›Paper›PMID 36747741›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals.

Hang Zhou, Rachel L Kember, Joseph D Deak, Heng Xu, Sylvanus Toikumo, Kai Yuan, Penelope A Lind, Leila Farajzadeh, Lu Wang, Alexander S Hatoum and 38 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

48 authors at 19 institutions in 3 countries.

Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Rachel L KemberCrescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Heng XuDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sylvanus ToikumoCrescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Kai YuanStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Leila FarajzadehDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
Lu WangDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Alexander S HatoumDepartment of Psychological and Brain Sciences, Washington University in St. Louis, Saint Louis, MO, USA.
Jessica JohnsonPamela Sklar Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hyunjoon LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Travis T MallardStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jiayi XuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Keira J A JohnstonDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Marco GalimbertiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Cecilia DaoVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Cassie OverstreetDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Nathan A GillespieInstitute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Scott GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Ian B HickieBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Ke XuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Laura M HuckinsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Lea K DavisVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Sandra Sanchez-RoigeDepartment of Medicine, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Tian GeStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jordan W SmollerStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Anders D BørglumDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
Ditte DemontisDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
John H KrystalDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
J Michael GazianoMassachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Million Veteran Program
Amy C JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Henry R KranzlerCrescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Yale University · USWashington University in St. Louis · USBroad Institute · USVeterans Health Administration · USAarhus University · DKQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USIndiana University School of MedicineMassachusetts General Hospital · USQueensland University of Technology · AUStatens Serum Institut · DKThe University of Sydney · AUUnited States Department of Veterans Affairs · USUniversity of California San Diego · USUniversity of Pennsylvania · USVanderbilt University Medical Center · USVirginia Commonwealth University · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Sherry Ann McKee · 2020 to 2026
$13.0M
PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6M
THE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4M
2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M
Molecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3M
7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M
Molecular Epidemiology of Alcoholism 2- Big SibshipsR01AA013320 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2003 to 2007
$3.1M
5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Genetic Epideniologic Models of Alcohol AbuseR37AA007728 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1998 to 2007
$2.2M
BLRD VA I01 BX003341BLRD VA I01 BX004820CSRD VA I01 CX001849Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR001878NCI NIH HHS R21 CA252916NIAAA NIH HHS K01 AA028292NIAAA NIH HHS K01 AA030083NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA026364NIAAA NIH HHS R37 AA007728NIAAA NIH HHS T32 AA028259NIAAA NIH HHS U54 AA027989NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS K08 DA019951NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA054869NIDA NIH HHS R56 DA012854NIH HHS S10 OD018522NIH HHS S10 OD026880NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124851NIMH NIH HHS U01 MH109514
6 · The paper itself

Abstract

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. To improve our understanding of the genetics of PAU, we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals. We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants in within- and cross-ancestry analyses. Cross-ancestry fine-mapping improved the identification of likely causal variants. Prioritizing genes through gene expression and/or chromatin interaction in brain tissues identified multiple genes associated with PAU. We identified existing medications for potential pharmacological studies by drug repurposing analysis. Cross-ancestry polygenic risk scores (PRS) showed better performance in independent sample than single-ancestry PRS. Genetic correlations between PAU and other traits were observed in multiple ancestries, with other substance use traits having the highest correlations. The analysis of diverse ancestries contributed significantly to the findings, and fills an important gap in the literature.

Identifiers

PMID36747741
PMCPMC9901058
OpenAlexW4318385195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.