Evidence map›Paper›PMID 36747731›Full record

ArticlebioRxiv : the preprint server for biology2023

Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin.

Kristine L Trotta, Beth M Hayes, Johannes P Schneider, Jing Wang, Horia Todor, Patrick Rockefeller Grimes, Ziyi Zhao, William L Hatleberg, Melanie R Silvis, Rachel Kim and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Kristine L TrottaDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
Beth M HayesDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
Johannes P SchneiderFocal Area Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH - 4056 Basel, Switzerland.
Jing WangFocal Area Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH - 4056 Basel, Switzerland.
Horia TodorDepartment of Cell and Tissue Biology, University of California - San Francisco, San Francisco, CA, USA.
Patrick Rockefeller GrimesDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
Ziyi ZhaoDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
William L HatlebergIndependent Researcher, Pittsburgh, Pennsylvania, USA.
Melanie R SilvisDepartment of Cell and Tissue Biology, University of California - San Francisco, San Francisco, CA, USA.
Rachel KimDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
Byoung Mo KooDepartment of Cell and Tissue Biology, University of California - San Francisco, San Francisco, CA, USA.
Marek BaslerFocal Area Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH - 4056 Basel, Switzerland.
Seemay ChouDepartment of Biochemistry & Biophysics, University of California - San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of Basel · CH

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
NIAID NIH HHS T32 AI060537
6 · The paper itself

Abstract

Gram-negative bacteria can antagonize neighboring microbes using a type VI secretion system (T6SS) to deliver toxins that target different essential cellular features. Despite the conserved nature of these targets, T6SS potency can vary across recipient species. To understand the molecular basis of intrinsic T6SS susceptibility, we screened for essential

Identifiers

PMID36747731
PMCPMC9900751
OpenAlexW4317672341

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.