Evidence map›Paper›PMID 36747657›Full record

ArticlebioRxiv : the preprint server for biology2023

Telomerase reactivation induces progression of mouse Braf

Iñigo Landa, Caitlin Em Thornton, Bin Xu, Jacob Haase, Gnana P Krishnamoorthy, Jingzhu Hao, Jeffrey A Knauf, Zachary T Herbert, María A Blasco, Ronald Ghossein and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Iñigo LandaDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Caitlin Em ThorntonDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Bin XuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jacob HaaseDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Gnana P KrishnamoorthyHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jingzhu HaoDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Jeffrey A KnaufLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Zachary T HerbertMolecular Biology Core Facilities, Dana-Farber Cancer Institute, Boston, MA, USA.
María A BlascoTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Ronald GhosseinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
James A FaginHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brigham and Women's Hospital · USMemorial Sloan Kettering Cancer Center · USCleveland Clinic Lerner College of Medicine · USDana-Farber Cancer Institute · USSpanish National Cancer Research Centre · ES

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
MOLECULAR PATHOPHYSIOLOGY OF THYROID CELL GROWTHR01CA050706 · NCI · UNIVERSITY OF CINCINNATI · PI FAGIN, JAMES A · 1995 to 2023
$7.5M
Improving efficacy of radioiodine treatment of thyroid cancerR01CA249663 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FAGIN, JAMES A, HO, ALAN L. · 2021 to 2025
$2.3M
TERT transcriptional deregulation in thyroid cancer progressionK22CA230381 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI LANDA-LOPEZ, INIGO · 2020 to 2022
$587k
NCI NIH HHS K22 CA230381NCI NIH HHS P30 CA006516NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA050706NCI NIH HHS R01 CA249663
6 · The paper itself

Abstract

Mutations in the promoter of the telomerase reverse transcriptase (

Identifiers

PMID36747657
PMCPMC9900760
OpenAlexW4317888662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.