Evidence map›Paper›PMID 36747540›Full record

ArticleHeliyon2023

Convenient synthesis, characterization and biological evaluation of novel 1-phenylcyclopropane carboxamide derivatives.

Panasa Mahesh, Parameswari Akshinthala, Ashok Reddy Ankireddy, Naresh Kumar Katari, Lavleen Kumar Gupta, Deepali Srivastava, Sreekantha Babu Jonnalagadda, Rambabu Gundla

Abstract read
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In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Panasa MaheshDepartment of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.
Parameswari AkshinthalaDepartment of Science and Humanities, MLR Institute of Technology, Dundigal, Medchal, Hyderabad, 500 043, India.
Ashok Reddy AnkireddyDepartment of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.
Naresh Kumar KatariDepartment of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.
Lavleen Kumar GuptaDrug Discovery Division, IgYImmunologix India Pvt Ltd, Hyderabad, Telangana, 500089 India.
Deepali SrivastavaDrug Discovery Division, IgYImmunologix India Pvt Ltd, Hyderabad, Telangana, 500089 India.
Sreekantha Babu JonnalagaddaSchool of Chemistry & Physics, College of Agriculture, Engineering & Science, University of KwaZulu-Natal, Westville Campus, P Bag X 54001, Durban, 4000, South Africa.
Rambabu GundlaDepartment of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small, strained ring molecules of phenylcyclopropane carboxamide have rigid, defined conformations and unique electronic properties. For these reasons many groups, seek to use these subunits to form biologically active compounds. Herein we report a generally applicable approach for preparing a small cyclopropane ring containing 1-phenylcyclopropane carboxamide derivatives to a wide range of the different aromatic compounds by α-alkylation of 2-phenyl acetonitrile derivatives with 1, 2-dibromo ethane in good yields followed by the conversion of cyano group to acid group by the reaction with concentrated hydrochloric acid. This obtained acid derivative undergoes acid amine coupling with various Methyl 2-(aminophenoxy)acetate to form 1-Phenylcyclopropane Carboxamide. These compounds possess distinct effective inhibition on the proliferation of U937, pro-monocytic, human myeloid leukaemia

Indexed as

AnticancerAntiproliferative agentsCytotoxicitySubstituted 1-phenylcyclopropane carboxamide derivatives

Identifiers

PMID36747540
PMCPMC9898299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.