ArticleThe Plant cell2023
PAT1-type GRAS-domain proteins control regeneration by activating DOF3.4 to drive cell proliferation in Arabidopsis roots.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
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- Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration.Molecular plant · 2026Article
- Dedifferentiation of Plant Cells: A Term Covering Multiple Pathways?Plants (Basel, Switzerland) · 2026Article
- A Statistical Mechanics Model to Decode Tissue Crosstalk During Graft Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- APlants (Basel, Switzerland) · 2026Article
- Identification and characterization of ninePlant signaling & behavior · 2025Article
- Mechanism and Application of Developmental Factors in Plant Genetic Transformation.International journal of molecular sciences · 2025Review
- Comparative phenotypic and transcriptomic analyses reveal the potential molecular basis of forming bigger leaf blade in autotetraploid castor bean.BMC plant biology · 2025Article
- The SCARECROW-LIKE transcription factor from Populus davidiana × P. bolleana simultaneously improved drought tolerance and plant growth through acetylation-dependent mechanisms.Plant biotechnology journal · 2025Article
- Genome-wide identification and functional analysis of the GRAS gene family in Medicago lupulina L.BMC genomics · 2025Article
- Comparative analysis of POD gene family and expression differentiation under NaCl, HBMC genomics · 2025Article
- The mechanism of PGR-free direct organogenesis in Lycium ruthenicum leaf explants revealed by RNA-Seq and phytohormone metabolome co-analysis.BMC plant biology · 2025Article
- Here comes the sun: integration of light, temperature, and auxin during herbaceous plant grafting.Planta · 2025Review
- Integration of Phytomelatonin Signaling With Jasmonic Acid in Wound-induced Adventitious Root Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Maize COMPACT PLANT 3 regulates plant architecture and facilitates high-density planting.The Plant cell · 2025Article
- The GRAS transcription factor PtrPAT1 ofHorticulture research · 2025Article
- Genome-wide association for multiple quantitative traits in forage oat germplasm based on specific length amplified fragment sequencing.Frontiers in plant science · 2025Article
- Phenylmercury stress induces root tip swelling through auxin homeostasis disruption.Plant molecular biology · 2024Article
- PagHAM4a-PagSCL21 and PagHAM4b-PagTCP20 modules positively regulate cambial activity and its differentiation into secondary xylem in poplar.Journal of experimental botany · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant roots possess remarkable regenerative potential owing to their ability to replenish damaged or lost stem cells. ETHYLENE RESPONSE FACTOR 115 (ERF115), one of the key molecular elements linked to this potential, plays a predominant role in the activation of regenerative cell divisions. However, the downstream operating molecular machinery driving wound-activated cell division is largely unknown. Here, we biochemically and genetically identified the GRAS-domain transcription factor SCARECROW-LIKE 5 (SCL5) as an interaction partner of ERF115 in Arabidopsis thaliana. Although nonessential under control growth conditions, SCL5 acts redundantly with the related PHYTOCHROME A SIGNAL TRANSDUCTION 1 (PAT1) and SCL21 transcription factors to activate the expression of the DNA-BINDING ONE FINGER 3.4 (DOF3.4) transcription factor gene. DOF3.4 expression is wound-inducible in an ERF115-dependent manner and, in turn, activates D3-type cyclin expression. Accordingly, ectopic DOF3.4 expression drives periclinal cell division, while its downstream D3-type cyclins are essential for the regeneration of a damaged root. Our data highlight the importance and redundant roles of the SCL5, SCL21, and PAT1 transcription factors in wound-activated regeneration processes and pinpoint DOF3.4 as a key downstream element driving regenerative cell division.
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