Evidence map›Paper›PMID 36747376›Full record

ArticleJournal of applied clinical medical physics2023

Cardiac motion and its dosimetric impact during radioablation for refractory ventricular tachycardia.

Joseph Harms, Eduard Schreibmann, Neal S Mccall, Michael S Lloyd, Kristin A Higgins, Richard Castillo

Open access · goldAbstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cardiac substructure delineation in radiation therapy - A state-of-the-art review.Journal of medical imaging and radiation oncology · 2024
    Review
  9. Radiation therapy for ventricular arrhythmias.Journal of medical imaging and radiation oncology · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph HarmsDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Eduard SchreibmannDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
Neal S MccallDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
Michael S LloydSection of Clinical Cardiac Electrophysiology, Emory University, Atlanta, Georgia, USA.
Kristin A HigginsDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
Richard CastilloDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
Emory University · USUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCardiac radioablation (CR) is a noninvasive treatment option for patients with refractory ventricular tachycardia (VT) during which high doses of radiation, typically 25 Gy, are delivered to myocardial scar. In this study, we investigate motion from cardiac cycle and evaluate the dosimetric impact in a cohort of patients treated with CR.

methodsThis retrospective study included eight patients treated at our institution who had respiratory-correlated and ECG-gated 4DCT scans acquired within 2 weeks of CR. Deformable image registration was applied between maximum systole (SYS) and diastole (DIAS) CTs to assess cardiac motion. The average respiratory-correlated CT (AVG

resultsMotion magnitudes were measured as the mean (SD) value over the DVFs within each structure. Displacement during the cardiac cycle for all chambers was 1.4 (0.9) mm medially/laterally (ML), 1.6 (1.0) mm anteriorly/posteriorly (AP), and 3.0 (2.8) mm superiorly/inferiorly (SI). Displacement for the 12 distinct clinical target volumes (CTVs) was 1.7 (1.5) mm ML, 2.4 (1.1) mm AP, and 2.1 (1.5) SI. Displacements between the AVG

conclusionsCardiac CTV motion in this patient cohort is on average below 3 mm, location-dependent, and when not accounted for in treatment planning may impact target coverage. Further study is needed to assess the impact of cardiac motion on clinical outcomes.

Indexed as

Radiotherapy Planning, Computer-AssistedTachycardia, VentricularFour-Dimensional Computed TomographyHumansRadiometryRetrospective Studiescardiac radioablationdeformable image registrationmotion managementSBRTventricular tachycardia

Identifiers

PMID36747376
PMCPMC10243314
OpenAlexW4319332836

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.