Evidence map›Paper›PMID 36747237›Full record

Observational studyBMC pulmonary medicine2023

Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis.

Xin Zou, Zhiyi Ma, Xiaohong Liu, Kaijun Zhang, Chenchen Qiu, Rongzhang Liang, Duanli Weng, Lingyan Xie, Xiaoming Cao, Yongquan Wu and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pulmonary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Bronchiectasis in Asia: a review of current status and challenges.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xin ZouPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China. cynthia3515@163.com.
Zhiyi MaPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China. fjlymzy@163.com.
Xiaohong LiuPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Kaijun ZhangPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Chenchen QiuRespiratory Department of Shanghang County Hospital, Longyan, 364000, China.
Rongzhang LiangPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Duanli WengPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Lingyan XiePulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Xiaoming CaoPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Yongquan WuPulmonary and Critical Care Medicine Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyibei Road, Longyan, 364000, China.
Liwen WenDepartment of Pharmaceutical Bussiness and Management, Sanming Medical and Polytechnic Vocational College, Sanming, 365000, China.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CNSanming University · CN

Funding

Fujian Provincial Health Technology Project 2018-1-98Start-up Funding for Scientific Research in Fujian Medical University 2017XQ1184
6 · The paper itself

Abstract

backgroundThe risk factors for osteoporosis and its prognostic value in patients with bronchiectasis is not well characterized. We explored the risk factors for osteoporosis and its prognostic impact in hospitalized non-cystic fibrosis bronchiectasis (NCFB) patients in Southeast China.

methodsThis observational cohort study consecutively enrolled 179 hospitalized patients with NCFB bronchiectasis between 2017 and 2021. The risk factors and the impact of osteoporosis on all-cause mortality were assessed.

results21.2% (38/179) of hospitalized NCFB patients were diagnosed with osteoporosis. Patients with osteoporosis had more severe symptoms (assessed by chronic airway assessment test, CAT, median 22 vs. 17, P = 0.017), poorer quality of life (assessed by St. George Respiratory Questionnaires, SQRC, median 42 vs. 27, P = 0.007), more severe disease stage (assessed by bronchiectasis severity index, BSI, median 14 vs. 11, P = 0.02), more comorbidities (assessed by Bronchiectasis Aetiology Comorbidity Index, BACI, median 5 vs. 4, P = 0.021) than patients without. Age, female sex, anemia, post-infection, and history of regular inhaled corticosteroid treatment were independent risk factors for osteoporosis in those patients. 21 patients (11.7%) died over a median follow-up period of 32 months. The all-cause mortality in NCFB patients with osteoporosis [28.94% (11/38)] was significantly higher than those without osteoporosis [7.09% (10/141)] [hazard ratio (HR) 5.34, 95% confidence interval (CI) 2.26-12.67, P < 0.001]. After adjusting for BSI and other confounding factors, osteoporosis was still independently associated with all-cause mortality in hospitalized NCFB patients (HR 4.29, 95% CI 1.75-10.49, P < 0.001).

conclusionsOsteoporosis had an independent effect on all-cause mortality in hospitalized NCFB patients. Management of comorbidities, including bone health, is a critical aspect of treating NCFB patients.

Indexed as

BronchiectasisCystic FibrosisOsteoporosisFemaleHumansPrognosisQuality of LifeRisk FactorsBronchiectasisComorbidityFragility fractureInfectionsMortalityOsteoporosisVitamin D

Identifiers

PMID36747237
PMCPMC9903403
OpenAlexW4319311739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.