ArticleBMC infectious diseases2023
Characteristics, risk factors and outcome of BKV nephropathy in kidney transplant recipients: a case-control study.
Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Incidence of BK Virus in HIV-positive Kidney Transplant Recipients: Case Series From South Africa.Transplantation direct · 2026Article
- Article
- Delayed Graft Function and Its Duration as Predictors of Medium-Term Kidney Transplant Outcomes: A Retrospective Cohort Study from an Eastern European Center.Journal of clinical medicine · 2025Article
- Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan.Iranian journal of microbiology · 2025Article
- Risk Factors for the Development of BK Polyomavirus and Treatment Outcomes in Kidney Transplant Recipients: An 8-Year Retrospective Cohort Study.Nephrology (Carlton, Vic.) · 2025Article
- Risk of cellular or antibody-mediated rejection in pediatric kidney transplant recipients with BK polyomavirus replication-an international CERTAIN registry study.Pediatric nephrology (Berlin, Germany) · 2025Article
- BK Virus Infection and Risk Factors in Kidney Transplant Recipients.Journal of clinical practice and research · 2025Article
- Tacrolimus Pharmacotherapy: Infectious Complications and Toxicity in Organ Transplant Recipients; An Updated Review.Current drug research reviews · 2025Review
- Risk factors and outcome of BK polyomavirus infection in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Polyomavirus nephropathy: diagnosis, histologic features, and differentiation from acute rejection.Clinical transplantation and research · 2024Review
- Dual roles of BK Polyomavirus in promoting urothelial carcinoma progression via regulating CLDN1.Biomarker research · 2024Article
- BK polyomavirus DNAemia in pancreas transplant recipients compared to pancreas-kidney recipients.Clinical transplantation · 2023Article
- Polyomavirus Wakes Up and Chooses Neurovirulence.Viruses · 2023Review
- Evaluating the Efficiency of the Cobas 6800 System for BK Virus Detection in Plasma and Urine Samples.Diagnostics (Basel, Switzerland) · 2023Article
- Impact of tacrolimus on interferon gamma ELISpot assay results for the assessment of T-cell immunity: Proof-of-concept.International journal of immunopathology and pharmacologyArticle
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing kidney transplantation, BK virus associated nephropathy (BKVN) occurs in 1 to 10% of kidney transplant recipients (KTR) and represents a major cause of graft loss. We aim at identifying factors associated with biopsy proven BKVN among KTR.
methodsWe conducted a retrospective case-control study including all KTR with a biopsy-proven diagnosis of BKVN between 2005 and 2019. Clinical characteristics and outcome were described. For each case, one control KTR without BKV infection was identified and matched by age, transplant date, and donor status. Factors associated with BKVN diagnosis were identified using exact conditional logistic regression. Comparative survival was described using Kaplan-Meier estimator.
resultsSixty-four cases of BKVN were identified among 1737 new kidney transplantation (3.7% prevalence). Clinical characteristics did not differ between groups, except for a higher c-PRA among cases. BKVN occurred in a median time of 11 (5-14.5) months after KT, and was associated with a significantly impaired graft function at diagnosis. Following BKVN, 61 (95%) of the patients had immunosuppression reduction, which led to BKV DNAemia resolution in 49% of cases. In multivariate analysis, factors associated with BKVN diagnosis were lymphopenia < 500/mm
conclusionsBKVN remains a severe complication in KTR and is associated with an increased risk for acute rejection and return to dialysis. Lymphopenia below 500/mm
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