Evidence map›Paper›PMID 36746875›Full record

Observational studyAIDS and behavior2023

Triple Benefit: Impact of an Integrated Early Childhood Development and PMTCT Intervention on ART Outcomes Among Mothers Living with HIV and Infants in Malawi-An Endline Evaluation.

Kathryn Dovel, Pericles Kalande, Evelyn Udedi, Laurie Bruns, Chris Desmond, Chipariro Mbalanga, Sundeep Gupta, Sam Phiri, Mackenzie Chivwala, Linda Richter and 1 more

Abstract readObservational Study
In one paragraph

Observational study in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathryn Dovel *Partners in Hope, Implementation Science, Lilongwe, Malawi. kdovel@mednet.ucla.edu.
Pericles Kalande *Partners in Hope, Implementation Science, Lilongwe, Malawi.
Evelyn UdediUniversity of California Global Health Institute, San Francisco, CA, USA.
Laurie BrunsUniversity of California Global Health Institute, San Francisco, CA, USA.
Chris DesmondStellenbosch University, Stellenbosch, South Africa.
Chipariro MbalangaPartners in Hope, Implementation Science, Lilongwe, Malawi.
Sundeep GuptaPartners in Hope, Implementation Science, Lilongwe, Malawi.
Sam PhiriPartners in Hope, Implementation Science, Lilongwe, Malawi.
Mackenzie ChivwalaPartners in Hope, Implementation Science, Lilongwe, Malawi.
Linda RichterUniversity of the Witwatersrand, Johannesburg, South Africa.
Thomas J CoatesDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y. · 1991 to 2018
$39.9M
Innovative strategies to increase ART Initiation and viral suppression among HIV+ men in MalawiK01TW011484 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOVEL, KATHRYN L · 2019 to 2023
$717k
FIC NIH HHS K01 TW011484FIC NIH HHS K01TW011484NIAID NIH HHS P30 AI028697NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

We conducted a programmatic, observational cohort study with mother-infant pairs (MIPs) enrolled in prevention-of-mother-to-child-transmission (PMTCT) programs in Malawi to assess the feasibility and potential HIV-related benefits of integrating Early Childhood Development (ECD) services into PMTCT programs. Six health facilities were included in the intervention. We offered ECD counseling from the WHO/UNICEF Care for Child Development package in PMTCT waiting spaces while MIPs waited for PMTCT and broader treatment consultations. Primary outcomes were mothers' retention in HIV care at 12 months and infant HIV testing at 6 weeks and 12 months after birth. Routine facility-level data from six comparison health facilities were collected as an adhoc standard of care comparison and used to calculate the cost of delivering the intervention. A total of 607 MIPs were enrolled in the integrated ECD-PMTCT intervention between June 2018 and December 2019. The average age of MIPs was 30 years and 7 weeks respectively. We found that 86% of mothers attended ≥ 5 of the 8 ECD sessions over the course of 12 months; 88% of intervention mothers were retained in PMTCT versus 59% of mothers in comparison health facilities, and 96% of intervention infants were tested for HIV by six weeks compared to 66% of infants in comparison health facilities. Costing data demonstrated the financial feasibility of integrating ECD and PMTCT programs in government health facilities in Malawi. Integrating ECD into PMTCT programs was feasible, acceptable, resulted in better programmatic outcomes for both mothers and infants. Further investigation is required to determine optimal delivery design for scale-up.

Indexed as

HIV InfectionsPregnancy Complications, InfectiousAdultChild DevelopmentChild, PreschoolFemaleHumansInfantInfectious Disease Transmission, VerticalMalawiMothersPregnancyChild developmentDelivery of Health CareHIVIntegratedMalawiMaternal-Child Health ServicesSub-Saharan Africa

Identifiers

PMID36746875
PMCPMC10338574

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.