Evidence map›Paper›PMID 36746614›Full record

ArticleThe British journal of ophthalmology2024

Collagen type XII is undetectable in keratoconus Bowman's layer.

Mohammed Rigi, Hyeck-Soo Son, Loren Moon, Mario Matthaei, Divya Srikumaran, Albert S Jun, Charles G Eberhart, Uri S Soiberman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Keratoconus.Nature reviews. Disease primers · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mohammed Rigi *Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Hyeck-Soo Son *Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.ORCID 0000-0003-1065-4035
Loren MoonWilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.ORCID 0000-0003-0216-9443
Mario MatthaeiDepartment of Ophthalmology, University Hospital Cologne, Cologne, Germany.
Divya SrikumaranWilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.ORCID 0000-0003-2366-235X
Albert S JunWilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Charles G EberhartWilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA usoiber1@jhmi.edu ceberha@jhmi.edu.
Uri S SoibermanWilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA usoiber1@jhmi.edu ceberha@jhmi.edu.ORCID 0000-0002-1678-6437
Johns Hopkins University · USUniversity Hospital Cologne · DE

Funding

The Role of Wnt-regulated Collagen Dysfunction in KeratoconusK08EY027474 · NEI · JOHNS HOPKINS UNIVERSITY · PI SOIBERMAN, URI SIMCHA · 2018 to 2021
$695k
NEI NIH HHS K08 EY027474
6 · The paper itself

Abstract

purposeCorneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII (

methodsTaqMan quantitative PCR was performed on 31 corneal epithelium samples of progressive KC and myopic control eyes. Tissue microarrays were constructed using full-thickness corneas from 61 KC cases during keratoplasty and 18 non-KC autopsy eyes and stained with an antibody specific to COL12A1. Additionally,

results

conclusionsThe apparent absence of COL12A1 in KC BL, together with the functional importance that

Indexed as

Epithelium, CornealKeratoconusCollagen Type XIICorneaHEK293 CellsHumansCollagen Type XIICorneaExperimental laboratoryPathology

Identifiers

PMID36746614
PMCPMC10466210
OpenAlexW4319304425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.