Evidence map›Paper›PMID 36746524›Full record

Trial reportBMJ paediatrics open2023

Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children.

Nigel J Hall, Frances C Sherratt, Simon Eaton, Erin Walker, Maria Chorozoglou, Lucy Beasant, Michael Stanton, Harriet Corbett, Dean Rex, Natalie Hutchings and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ paediatrics open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nigel J HallUniversity Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, UK n.j.hall@soton.ac.uk.ORCID 0000-0001-8570-9374
Frances C SherrattDepartment of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK.ORCID 0000-0003-4147-9305
Simon EatonUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0003-0892-9204
Erin WalkerGreat Ormond Street Hospital For Children NHS Trust, London, UK.
Maria ChorozoglouSouthampton Health Technology Assessment Centre, University of Southampton Faculty of Medicine, Southampton, UK.ORCID 0000-0001-5070-4653
Lucy BeasantCentre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK.
Michael StantonDepartment of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, UK.
Harriet CorbettDepartment of Surgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Dean RexPaediatric Surgery, St George's University Hospitals NHS Foundation Trust, London, UK.
Natalie HutchingsSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Elizabeth DixonSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Esther CrawleyCentre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-2521-0747
Jane BlazebyBristol and Weston Biomedical Research Centre, Population Health Sciences, University of Bristol, Bristol, UK.
Bridget YoungDepartment of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK.
Isabel ReadingPrimary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.

Funding

Medical Research Council MR/K025643/1
6 · The paper itself

Abstract

While non-operative treatment has emerged as an alternative to surgery for the treatment of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these in a feasibility randomised trial. Of 57 randomised participants, data were available for 26. Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorter duration of requiring analgesia, more rapid return to normal activities and shorter parental absence from work. These preliminary data suggest differences exist in recovery profile and quality of life between these treatments that are important to measure in a larger RCT. Trial registration number is ISRCTN15830435.

Indexed as

Anti-Bacterial AgentsAppendicitisAcute DiseaseAppendectomyChildFeasibility StudiesHumansPain ManagementQuality of LifeAnti-Bacterial AgentsGastroenterology

Identifiers

PMID36746524
PMCPMC9906255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.