Evidence map›Paper›PMID 36746394›Full record

ArticleCancer reports (Hoboken, N.J.)2023

The association of blood ctDNA levels to mutations of marker genes in colorectal cancer.

Fei Bai, Qian Du, Qingliang Zou, Lin Xu, Wei Dong, Xinlin Lv, Xiaorong Han, Huijun Zhou, Chi Zhang, Tao Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Fei BaiHunan Cancer Hospital and The Affiliated cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Qian DuSchool of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA.
Qingliang ZouChengdu Medical College, Chengdu, Sichuan, China.
Lin XuSichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Wei DongDepartment of oncology, Chengdu Ping-An Hospital, Chengdu, Sichuan, China.
Xinlin LvChengdu Women and Children's Center Hospital, Chengdu, Sichuan, China.
Xiaorong HanChengdu Women and Children's Center Hospital, Chengdu, Sichuan, China.
Huijun ZhouHunan Cancer Hospital and The Affiliated cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Chi ZhangSchool of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA.ORCID 0000-0002-1827-8137
Tao LuChengdu Medical College, Chengdu, Sichuan, China.
Central South University · CNChengdu Medical College · CNChengdu Women's and Children's Central Hospital · CNUniversity of Nebraska–Lincoln · USSichuan Cancer Hospital · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a deadly and commonly diagnosed cancer. Cell-free circulating tumor DNAs (ctDNA) have been used in the diagnosis and treatment of CRC, but there are open questions about the relationship between ctDNAs and CRC. Although mutations of genes detected by ctDNA in CRC have been studied, the quantitative relationship between ctDNA mutations and ctDNA concentration has not been addressed.

aimsWe hypothesized that there was an association between mutations of genes identified in ctDNAs and ctDNA concentration. His study examined this association in a population of CRC patients.

methodsIn 85 CRC patients, we sampled 282 mutations in 36 genes and conducted an association study based on a Random forest model between mutations and ctDNA concentrations in all patients.

resultsThis association study showed that mutations on five genes, ALK, PMS2, KDR, MAP2K1, and MSH2, were associated with the ctDNA concentrations in CRC patients' blood samples. Because ctDNA mutations correlate with ctDNA level, we can infer the tumor burden or tumor size from ctDNA mutations, as well as the survival time for prognosis.

conclusionOur findings shed light on the associations between mutations of genes identified in ctDNAs and ctDNA concentration in the blood of CRC patients. This discovery provides information regarding the tumor burden or tumor size based on ctDNA mutations.

Indexed as

Circulating Tumor DNAColorectal NeoplasmsHumansMutationPrognosisCirculating Tumor DNAassociation studycell-free circulating tumor DNAs (ctDNA)colorectal cancer (CRC)genomic variationsrandom forest

Identifiers

PMID36746394
PMCPMC10075297
OpenAlexW4319299918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.