ArticlePloS one2023
Modelling of thrombus formation using smoothed particle hydrodynamics method.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mesoscale Simulations of Blood Coagulation in Flow and Quiescent Domains Using SDPD.International journal for numerical methods in biomedical engineering · 2026Article
- Thromboembolism in the left atrial appendage under atrial fibrillation and after sinus rhythm restoration: a computational study.Frontiers in bioengineering and biotechnology · 2026Article
- Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation,Frontiers in bioengineering and biotechnology · 2025Review
- [Progress in the analysis of hemolysis and coagulation models for interventional micro-axial flow blood pumps].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Investigating the pathophysiology and evolution of internal carotid dissection: a fluid-structure interaction simulation study.Frontiers in neurology · 2024Article
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Authors and funding
4 authors.
Funding
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Abstract
In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.
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