Evidence map›Paper›PMID 36745528›Full record

ArticleAmerican journal of physiology. Cell physiology2023

Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca

Rolando Carrisoza-Gaytan, Katharina T Kroll, Ken Hiratsuka, Navin R Gupta, Ryuji Morizane, Jennifer A Lewis, Lisa M Satlin

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. CaAmerican journal of physiology. Cell physiology · 2025
    Article
  5. Review
  6. Epithelial tubule interconnection driven by HGF-Met signaling in the kidney.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rolando Carrisoza-GaytanDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States.ORCID 0000-0001-8771-9269
Katharina T KrollPaulson School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States.
Ken HiratsukaPaulson School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States.
Navin R GuptaNephrology Division, Massachusetts General Hospital, Boston, Massachusetts, United States.
Ryuji MorizanePaulson School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States.
Jennifer A LewisPaulson School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States.
Lisa M SatlinDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States.ORCID 0000-0002-1744-1748
Harvard University · USIcahn School of Medicine at Mount Sinai · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Mechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2M
Ex Vivo Generation of Functional Kidney Tissues for TransplantationUC2DK126023 · NIDDK · HARVARD UNIVERSITY · PI LEWIS, JENNIFER A. · 2020 to 2024
$4.0M
Recreating Kidney Organogenesis in vitro with Human Pluripotent Stem CellsDP2DK133821 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MORIZANE, RYUJI · 2019 to 2019
$2.5M
Role of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01DK127587 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2020 to 2022
$2.1M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01EB028899 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2019 to 2019
$748k
Development of a fluidic chip model of PKD to elucidate cystogenic signals using kidney organoidsR21DK129909 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MORIZANE, RYUJI · 2022 to 2022
$216k
NIBIB NIH HHS U01 EB028899NIDDK NIH HHS DP2 DK133821NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R01 DK039773NIDDK NIH HHS R01 DK129285NIDDK NIH HHS R21 DK129909NIDDK NIH HHS U01 DK127587NIDDK NIH HHS UC2 DK126023
6 · The paper itself

Abstract

Kidney organoids cultured on adherent matrices in the presence of superfusate flow generate vascular networks and exhibit more mature podocyte and tubular compartments compared with static controls (Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Scott M, Miyoshi T, Mau D, Valerius MT, Ferrante T, Bonventre JV, Lewis JA, Morizane R.

Indexed as

CalciumCalcium SignalingKidney TubulesAnimalsFura-2Ion ChannelsKidneyMiceCalciumFura-2Ion ChannelsPiezo1 protein, mousedevelopmentfluid flowmechanoregulationmicroperfusionsignal transduction

Identifiers

PMID36745528
PMCPMC10027089
OpenAlexW4319294170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.