Evidence map›Paper›PMID 36745416›Full record

ArticleACS chemical neuroscience2023

Amyloid Fibers of α-Synuclein Catalyze Chemical Reactions.

Istvan Horvath, Pernilla Wittung-Stafshede

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Catalytic Amyloids: Turning Fibrils Into Biocatalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Article
  3. The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. ATP Hydrolysis by α-Synuclein Amyloids is Mediated by Enclosing β-Strand.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. CAPIM: Catalytic activity and site prediction and analysis tool in multimer proteins.Protein science : a publication of the Protein Society · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Biological Amyloids Chemically Damage DNA.ACS chemical neuroscience · 2025
    Article
  13. Article
  14. Copper ion incorporation in α-synuclein amyloids.Protein science : a publication of the Protein Society · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Chemical catalysis by biological amyloids.Biochemical Society transactions · 2023
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Istvan HorvathDepartment of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Pernilla Wittung-StafshedeDepartment of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Chalmers University of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid fibers of the protein α-synuclein, found in Lewy body deposits, are hallmarks of Parkinson's disease. We here show that α-synuclein amyloids catalyze biologically relevant chemical reactions in vitro. Amyloid fibers, but not monomers, of α-synuclein catalyzed hydrolysis of the model ester

Indexed as

alpha-SynucleinParkinson DiseaseAmyloidHumansLewy Bodiesalpha-SynucleinAmyloidamyloid fibersCatalysiscatalytic efficiencyParkinson’s diseaseα-synuclein

Identifiers

PMID36745416
PMCPMC9936539
OpenAlexW4319294428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.