Evidence map›Paper›PMID 36745354›Full record

ReviewMolecular imaging and biology2023

Practical Guidance for Developing Small-Molecule Optical Probes for In Vivo Imaging.

Chongzhao Ran, James R Mansfield, Mingfeng Bai, Nerissa T Viola, Abhishek Mahajan, E James Delikatny

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Molecular Afterglow of Lophine-Based Luminophore and Its Imaging Applications.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Room 2301, Building 149, Charlestown, Boston, MA, 02129, USA. cran@nmr.mgh.harvard.edu.ORCID 0000-0002-3892-4108
James R MansfieldVisiopharm A/S, Agern Alle 24, 2970, Hørsholm, Denmark. mansfieldjamesr@gmail.com.
Mingfeng BaiDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Nerissa T ViolaDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA.
Abhishek MahajanDepartment of Radiology, The Clatterbridge Cancer Centre NHS Foundation Trust, Pembroke Place, Liverpool, L7 8YA, UK.
E James DelikatnyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. delikatn@pennmedicine.upenn.edu.
Clatterbridge Cancer Centre NHS Foundation Trust · GBHarvard University · USMansfield University · USUniversity of Pennsylvania · USVanderbilt University Medical Center · USWayne State University · US

Funding

Shared Resource - Core A: Administrative CoreP01CA254859 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Sunil Singhal · 2022 to 2026
$10.0M
Translating phospholipase activatable fluorophores for the sensitive detection of non-small cell lung cancerR01CA266234 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD J DELIKATNY, Sunil Singhal · 2022 to 2026
$2.4M
Near infrared fluorescence imaging of reactive oxygen species in Alzheimer's diseaseR01AG055413 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2018 to 2022
$2.1M
Near-infrared Choline Kinase Sensors for Intraoperative Identification of Lung Tumor MarginsR01CA226412 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DELIKATNY, EDWARD J, SINGHAL, SUNIL · 2018 to 2022
$1.8M
Upgrade and replacement of IVIS Spectrum imaging systemS10OD028609 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2020 to 2020
$600k
Fluorescence ocular imaging for preliminarily screening of Alzheimer'sR56AG059814 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2019 to 2019
$572k
Near infrared Fluorescence Ocular Imaging of Soluble Amyloid Beta SpeciesR21AG059134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2018 to 2019
$459k
NIH HHS P01CA254859NIH HHS R01AG055413NIH HHS R01CA226412NIH HHS R01CA266234NIH HHS R21AG059134NIH HHS R56AG059814NIH HHS S10OD028609
6 · The paper itself

Abstract

The WMIS Education Committee (2019-2022) reached a consensus that white papers on molecular imaging could be beneficial for practitioners of molecular imaging at their early career stages and other scientists who are interested in molecular imaging. With this consensus, the committee plans to publish a series of white papers on topics related to the daily practice of molecular imaging. In this white paper, we aim to provide practical guidance that could be helpful for optical molecular imaging, particularly for small molecule probe development and validation in vitro and in vivo. The focus of this paper is preclinical animal studies with small-molecule optical probes. Near-infrared fluorescence imaging, bioluminescence imaging, chemiluminescence imaging, image-guided surgery, and Cerenkov luminescence imaging are discussed in this white paper.

Indexed as

Molecular ImagingOptical ImagingAnimalsFluorescent DyesFluorescent DyesFluorescence imaging guided surgeryMolceular imagingNear-infrared fluorescence imagingSmall molecule fluorescence probes

Identifiers

PMID36745354
OpenAlexW4319295117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.