Evidence map›Paper›PMID 36745300›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Worldwide prevalence of neuromyelitis optica spectrum disorder (NMOSD) and neuromyelitis optica (NMO): a systematic review and meta-analysis.

Sara Bagherieh, Alireza Afshari-Safavi, Saeed Vaheb, Mahsa Kiani, Elham Moases Ghaffary, Mahdi Barzegar, Vahid Shaygannejad, Aram Zabeti, Omid Mirmosayyeb

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Area postrema syndrome and longitudinally extensive transverse myelitis masquerading as leptomeningeal carcinomatosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sara BagheriehIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Alireza Afshari-SafaviDepartment of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Saeed VahebIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahsa KianiIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Elham Moases GhaffaryIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahdi BarzegarIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Vahid ShaygannejadIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Aram ZabetiDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
Omid MirmosayyebIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. omid.mirmosayyeb@gmail.com.ORCID http://orcid.org/0000-0002-3756-2985

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuromyelitis optica spectrum disorder (NMOSD) is a progressive demyelinating disease of the central nervous system that has overlapping symptoms with multiple sclerosis (MS) but differs from it in a variety of ways. Previous studies have reported conflicting results trying to estimate the number of individuals affected by them which is why we designed this systematic review and meta-analysis to estimate the worldwide prevalence and incidence of NMOSD/NMO based on current evidence.

methodsWe searched PubMed, Scopus, EMBASE, Web of Science, and gray literature including references from the identified studies, review studies, and conference abstracts which were published up to February 1, 2022. We used all MeSH terms pertaining to "NMOSD," "NMO," and all the terms on "prevalence," "incidence," and "epidemiology" to identify the search components. Pooled effect sizes were measured using random-effect model by DerSimonian-Laird.

resultsThe prevalence and incidence rates of NMOSD/NMO ranged from 0.07 to 10 and 0.029 to 0.880 per 100,000 population, respectively. The overall pooled prevalence of NMO per 100,000 population was 1.54 (I

conclusionAlthough rare, NMOSD/NMO impact affected individuals in devastating ways. Several large-scale prospective studies are required to reach a comprehension of the epidemiological aspects of these notorious demyelinating conditions.

Indexed as

Multiple SclerosisNeuromyelitis OpticaCentral Nervous SystemFemaleHumansIncidenceMalePrevalenceIncidenceNeuromyelitis optica spectrum disorderNMONMOSDPrevalence

Identifiers

PMID36745300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.