Evidence map›Paper›PMID 36745280›Full record

ReviewInternal and emergency medicine2023

Inflammatory biomarkers of ischemic stroke.

Amedeo Tirandi, Cosimo Sgura, Federico Carbone, Fabrizio Montecucco, Luca Liberale

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amedeo Tirandi *Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy.
Cosimo Sgura *Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy.
Federico CarboneDepartment of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy.
Fabrizio MontecuccoDepartment of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy. fabrizio.montecucco@unige.it.ORCID 0000-0003-0823-8729
Luca LiberaleDepartment of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.

Indexed as

Brain IschemiaIschemic StrokeStrokeBiomarkersCytokinesHumansInflammationBiomarkersCytokinesAdhesion moleculesAdipocytokinesCytokinesInflammationStroke

Identifiers

PMID36745280
PMCPMC10082112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.