ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2023
Infection burdens and virulence under heat stress: ecological and evolutionary considerations.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- Nocturnal warming and emergency department admissions: a nationwide association and projection study in Singapore.BMC emergency medicine · 2026Article
- Status and advancement of root-knot nematode management strategies and the emerging CRISPR/Cas biotechnology application.Functional & integrative genomics · 2026Review
- Thermal adaptation inProceedings. Biological sciences · 2025Article
- Review
- Warming During Different Life Stages has Distinct Impacts on Host Resistance Ecology and Evolution.Ecology letters · 2025Article
- Adaptive evolution of stress response genes in parasites aligns with host niche diversity.BMC biology · 2025Article
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- Cold snaps lead to a 5-fold increase or a 3-fold decrease in disease proliferation depending on the baseline temperature.BMC biology · 2024Article
- Warming alters life-history traits and competition in a phage community.Applied and environmental microbiology · 2024Article
- Dual stressors of infection and warming can destabilize host microbiomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Into the danger zone: How the within-host distribution of parasites controls virulence.Ecology letters · 2024Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Infectious disease ecology and evolution in a changing world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Editorial: Parasitism: the good, the bad and the ugly.Frontiers in veterinary science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a result of global change, hosts and parasites (including pathogens) are experiencing shifts in their thermal environment. Despite the importance of heat stress tolerance for host population persistence, infection by parasites can impair a host's ability to cope with heat. Host-parasite eco-evolutionary dynamics will be affected if infection reduces host performance during heating. Theory predicts that within-host parasite burden (replication rate or number of infecting parasites per host), a key component of parasite fitness, should correlate positively with virulence-the harm caused to hosts during infection. Surprisingly, however, the relationship between within-host parasite burden and virulence during heating is often weak. Here, we describe the current evidence for the link between within-host parasite burden and host heat stress tolerance. We consider the biology of host-parasite systems that may explain the weak or absent link between these two important host and parasite traits during hot conditions. The processes that mediate the relationship between parasite burden and host fitness will be fundamental in ecological and evolutionary responses of host and parasites in a warming world. This article is part of the theme issue 'Infectious disease ecology and evolution in a changing world'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.