ArticleCirculation research2023
Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.
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Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- CHI3L1: a novel regulator of vascular remodeling in pulmonary arterial hypertension.Molecular and cellular biochemistry · 2026Article
- Advances in the pathogenesis and clinical management of pulmonary hypertension.Medical review (2021) · 2026Review
- S- nitrosylation of Annexin A2 at Cys133 ameliorates pulmonary arterial hypertension by inhibiting the WNT/β-catenin pathway.Respiratory research · 2026Article
- The Role of the Apelin Receptor in the Pathophysiology of Pulmonary Arterial Hypertension.Cells · 2026Review
- Article
- A second-hit conceptual framework for pulmonary arterial hypertension in adult congenital heart disease: genetics, hemodynamics, and treat-and-repair.Frontiers in cardiovascular medicine · 2026Review
- Fenofibrate as a Modulator of the Renin-Angiotensin System in Su/Hx-Induced Pulmonary Arterial Hypertension.International journal of molecular sciences · 2025Article
- Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Response to Dr. Nicholas A. Flavahan's and Dr. Ali H. Eid's letters regarding our recent publication in Cell Genomics.Cell genomics · 2025Article
- Exploring hypoxia driven subtypes of pulmonary arterial hypertension through transcriptomics single cell sequencing and machine learning.Scientific reports · 2025Article
- Association of interferon regulator factor 1 upregulation with pulmonary arterial hypertension.Journal of thoracic disease · 2025Article
- Emerging Mechanistic Insights and Therapeutic Strategies for Pulmonary Arterial Hypertension: A Focus on Right Ventricular Dysfunction and Novel Treatment Pathways.Biomedicines · 2025Review
- Review
- High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension.PloS one · 2025Article
- Emodin Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Directly Targeting TAK1.Drug design, development and therapy · 2025Article
- Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.Circulation · 2024Article
- Carotid Baroreceptor Stimulation Ameliorates Pulmonary Arterial Remodeling in Rats With Hypoxia-Induced Pulmonary Hypertension.Journal of the American Heart Association · 2024Article
- Pathology and pathobiology of pulmonary hypertension: current insights and future directions.The European respiratory journal · 2024Review
- Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: From Bedside to Bench and Back Again.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Lingli WangBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital (L.W., J.R.M., A.C., S.I., M.R.), Stanford University School of Medicine, CA.
Jan-Renier MoonenBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital (L.W., J.R.M., A.C., S.I., M.R.), Stanford University School of Medicine, CA.ORCID 0000-0002-0361-824X
Aiqin CaoBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital (L.W., J.R.M., A.C., S.I., M.R.), Stanford University School of Medicine, CA.
Sarasa IsobeBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital (L.W., J.R.M., A.C., S.I., M.R.), Stanford University School of Medicine, CA.
Caiyun G LiVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
Nancy F TojaisVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
Shalina TaylorVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
David P MarcianoStanford Cardiovascular Institute (L.W., J.R.M., A.C., S.I., C.G.L., S.T., D.P.M., P.-I.C., M.G., D.L., R.L.H., M.R.), Stanford University School of Medicine, CA.
Pin-I ChenVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
Mingxia GuVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.ORCID 0000-0001-7405-8473
Dan LiVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
Rebecca L HarperVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.ORCID 0000-0003-1465-7372
Nesrine El-BizriVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.ORCID 0000-0003-3079-9792
Yu-Mee KimVera Moulton Wall Center for Pulmonary Vascular Diseases (L.W., J.R.M., A.C., S.I., C.G.L., N.F.T., S.T., P.-I.C., M.G., D.L., R.L.H., N.E.-B., Y.M.K., M.R.), Stanford University School of Medicine, CA.
Kryn StankunasDepartment of Medicine (K.S.); Stanford University School of Medicine, CA.
Marlene RabinovitchBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital (L.W., J.R.M., A.C., S.I., M.R.), Stanford University School of Medicine, CA.ORCID 0000-0001-7886-7104
Cardiovascular Institute of the South · USLucile Packard Children's Hospital · USMahindra and Mahindra Limited (India) · INStanford University · US
Funding
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2MThe Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2011 to 2021
$19.7MPulmonary Hypertension in Genetically Modified MiceR01HL074186 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2004 to 2022
$10.4MPulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MThe BMP-PPARy Axis and Pulmonary HypertensionR01HL087118 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2008 to 2022
$7.2MStanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2MElucidating the FOXF1 gene regulatory network in human alveologenesisR01HL166283 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mingxia Gu · 2023 to 2026
$1.9MUncovering compensatory mechanisms in family members with disease causing mutations of pulmonary hypertensionR00HL135258 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI GU, MINGXIA · 2020 to 2022
$747kTherapeutic Rescue of a Deficient BMPR2 Hypoxic Response in Pulmonary Arterial HypertensionR00HL145097 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI MARCIANO, DAVID P · 2022 to 2024
$747kUncovering compensatory mechanisms in family members with disease causing mutations of pulmonary hypertensionK99HL135258 · NHLBI · STANFORD UNIVERSITY · PI GU, MINGXIA · 2017 to 2018
$336kTherapeutic Rescue of a Deficient BMPR2 Hypoxic Response in Pulmonary Arterial HypertensionK99HL145097 · NHLBI · STANFORD UNIVERSITY · PI MARCIANO, DAVID P · 2019 to 2020
$221kNCRR NIH HHS UL1 RR024986NHLBI NIH HHS K99 HL135258NHLBI NIH HHS K99 HL145097NHLBI NIH HHS P01 HL108797NHLBI NIH HHS R00 HL135258NHLBI NIH HHS R00 HL145097NHLBI NIH HHS R01 HL074186NHLBI NIH HHS R01 HL087118NHLBI NIH HHS R01 HL166283NHLBI NIH HHS R24 HL123767NHLBI NIH HHS T32 HL129970
Abstract
objectiveMutations in
methodsSMC-specific
results
conclusionsAgents that neutralize the elevated ARRB2 resulting from loss of BMPR2 in PASMC could prevent or reverse the aberrant hypocontractile and hyperproliferative phenotype of these cells in PAH.
Indexed as
Hypertension, PulmonaryPulmonary Arterial HypertensionAnimalsbeta-Arrestin 2Bone Morphogenetic Protein Receptors, Type IICell ProliferationCells, CulturedEndothelial CellsGlycogen Synthase Kinase 3HumansHypoxiaMiceMyocytes, Smooth MusclePulmonary ArteryRNAARRB2 protein, humanArrb2 protein, mousebeta-Arrestin 2BMPR2 protein, humanBmpr2 protein, mouseBone Morphogenetic Protein Receptors, Type IIGlycogen Synthase Kinase 3RNAbeta-arrestin 2bone morphogenetic protein receptors, type IIpulmonary arterial hypertensionsmooth muscle cellstransgenic mice
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