ArticleCirculation research2023
Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human
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Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
What it found
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Elucidating the cellular determinants of the end-systolic pressure-volume relationship of the heart via computational modelling.The Journal of physiology · 2026Article
- Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM.APL bioengineering · 2026Article
- Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Review
- Cryopreservation alters contractile function of human induced pluripotent stem cell-derived cardiomyocytes.Scientific reports · 2026Article
- Beta-Adrenergic Stimulation andbioRxiv : the preprint server for biology · 2026Article
- Article
- Variable cMyBP-C expression from cell to cell in a MYBPC3Stem cell research & therapy · 2026Article
- Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation.Cells · 2025Review
- Resolving zone-specific regulation of cardiac myosin.The Journal of general physiology · 2025Article
- MYBPC3 c.2309-2A>G: exploring a founder variant in Italian hypertrophic cardiomyopathy patients.European journal of human genetics : EJHG · 2025Article
- Myosin-binding protein C slows cardiac myofibril relaxation kinetics.The Journal of physiology · 2025Article
- Lower left ventricular ejection time in MYBPC3 variant carriers with overt or subclinical hypertrophic cardiomyopathy.ESC heart failure · 2025Article
- Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity.The Journal of general physiology · 2025Article
- Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review.JACC. Basic to translational science · 2025Review
- AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models.Nature communications · 2025Article
- Case report: Severe arrhythmogenic cardiomyopathy in a young girl with compound heterozygousFrontiers in genetics · 2025Article
- The N-Terminal Mutations of cMyBP-C Affect Calcium Regulation, Kinetics, and Force of Muscle Contraction.International journal of molecular sciences · 2024Article
- Clinical trials in-a-dish for cardiovascular medicine.European heart journal · 2024Review
- The D75N and P161S Mutations in the C0-C2 Fragment of cMyBP-C Associated with Hypertrophic Cardiomyopathy Disturb the Thin Filament Activation, Nucleotide Exchange in Myosin, and Actin-Myosin Interaction.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
25 authors at 13 institutions in 8 countries.
Josè Manuel Pioner *Department of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.
Giulia Vitale *Department of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.ORCID 0000-0003-3790-8461
Sonette SteczinaDepartment of Bioengineering, University of Washington, Seattle, WA (S.S., M.R.).ORCID 0000-0002-5415-828X
Marianna LangioneDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.ORCID 0000-0002-7783-2177
Francesca MargaraDepartment of Computer Science, University of Oxford, United Kingdom (F. Margara, A.B.-O.).ORCID 0000-0003-2792-7087
Lorenzo SantiniDepartment of NeuroFarBa (L. Santini, C. Palandri, V. Spinelli, E. Cerbai, R. Coppini), University of Florence, Italy.
Francesco GiardiniEuropean Laboratory for Non-Linear Spectroscopy (LENS) (F. Giardini, E. Lazzeri, C.F., C.P., E. Cerbai), University of Florence, Italy.ORCID 0000-0001-8301-2864
Erica LazzeriEuropean Laboratory for Non-Linear Spectroscopy (LENS) (F. Giardini, E. Lazzeri, C.F., C.P., E. Cerbai), University of Florence, Italy.
Nicoletta PiroddiDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.ORCID 0000-0001-8424-9054
Beatrice ScelliniDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.
Chiara PalandriDepartment of NeuroFarBa (L. Santini, C. Palandri, V. Spinelli, E. Cerbai, R. Coppini), University of Florence, Italy.ORCID 0000-0002-6286-8089
Maike SchuldtAmsterdam University Medical Center, Vrije Universiteit Amsterdam, Physiology, The Netherlands (M.S., J.v.d.V.).ORCID 0000-0001-9401-6190
Valentina SpinelliDepartment of NeuroFarBa (L. Santini, C. Palandri, V. Spinelli, E. Cerbai, R. Coppini), University of Florence, Italy.
Francesca GirolamiPediatric Cardiology (F. Girolami), IRCCS Meyer Children's Hospital, Florence, Italy.ORCID 0000-0001-9143-3597
Francesco MazzarottoDepartment of Molecular and Translational Medicine, University of Brescia, Italy (F. Mazzarotto).ORCID 0000-0002-6159-9980
Jolanda van der VeldenAmsterdam University Medical Center, Vrije Universiteit Amsterdam, Physiology, The Netherlands (M.S., J.v.d.V.).ORCID 0000-0001-5224-5788
Elisabetta CerbaiDepartment of NeuroFarBa (L. Santini, C. Palandri, V. Spinelli, E. Cerbai, R. Coppini), University of Florence, Italy.ORCID 0000-0001-7839-1361
Chiara TesiDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.
Iacopo OlivottoCardiogenetics Unit (I.O.), IRCCS Meyer Children's Hospital, Florence, Italy.ORCID 0000-0003-1751-9266
Alfonso Bueno-OrovioDepartment of Computer Science, University of Oxford, United Kingdom (F. Margara, A.B.-O.).ORCID 0000-0002-1634-3601
Leonardo SacconiInstitute of Clinical Physiology (IFC), National Research Council, Florence, Italy (L. Sacconi).
Raffaele CoppiniDepartment of NeuroFarBa (L. Santini, C. Palandri, V. Spinelli, E. Cerbai, R. Coppini), University of Florence, Italy.ORCID 0000-0002-4096-3173
Cecilia FerrantiniDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.ORCID 0000-0002-3757-1363
Michael RegnierDepartment of Bioengineering, University of Washington, Seattle, WA (S.S., M.R.).ORCID 0000-0001-5437-9851
Corrado PoggesiDepartment of Clinical and Experimental Medicine, Division of Physiology (J.M.P., G.V., M.L., N.P., B.S., C.T., C.F., C. Poggesi), University of Florence, Italy.ORCID 0000-0003-2624-4778
University of Florence · ITEuropean University Institute · ITMeyer Children's Hospital · ITQueen Margaret University · GBUniversity of Washington · USVrije Universiteit Amsterdam · NLFerioli & Gianotti (Italy) · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITSanofi (France) · FRSan Raffaele University of Rome · ITSantissima Trinità · ITUnited Cerebral Palsy · USUniversity of Freiburg · DE
Funding
UW Center for Translational Muscle Research (Overall Application)P30AR074990 · NIAMS · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis, DANIEL RAFTERY · 2019 to 2026
$7.5MEngineered Stem Cells for Cardiac RepairR01HL128368 · NHLBI · UNIVERSITY OF WASHINGTON · PI REGNIER, MICHAEL · 2018 to 2025
$6.1MBritish Heart Foundation FS/17/22/32644NHLBI NIH HHS R01 HL128368
Abstract
backgroundThe pathogenesis of
methodsWe collected clinical and genetic data from 93 HCM patients carrying the
resultsHaplotype analysis revealed
conclusionsHCM-related
Indexed as
Cardiomyopathy, HypertrophicInduced Pluripotent Stem CellsCalciumCalcium, DietaryCarrier ProteinsCytoskeletal ProteinsHumansMutationMyocardiumMyocytes, CardiacCalciumCalcium, DietaryCarrier ProteinsCytoskeletal Proteinsfounder effecthypertrophic cardiomyopathymyosin binding protein-Cpersonalized medicinesarcomere energetics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.