Evidence map›Paper›PMID 36744350›Full record

ArticleJournal of neonatal-perinatal medicine2023

Correlation of placental pathology with the postoperative outcomes and white matter injury in preterm infants following necrotizing enterocolitis.

P M Garg, J L Paschal, M A Y Ansari, J Ware, K Adams, C Taylor, K Reddy, C R Rosenfeld, I N Mir

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. [Risk factors for white matter damage in preterm infants with necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

P M GargDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
J L PaschalDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
M A Y AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
J WareDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
K AdamsDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
C TaylorDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
K ReddyDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
C R RosenfeldDepartment of Pediatrics/Neonatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
I N MirDepartment of Pediatrics/Neonatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
University of Mississippi Medical Center · USThe University of Texas Southwestern Medical Center · USJackson Memorial Hospital · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundTo determine the association of placental pathologic lesions with postoperative outcomes, survival, and white matter injury (WMI) in preterm infants with NEC.

methodsA retrospective chart review of 107 neonates with NEC (Bell stage > IIa) from Jan 2013- June 2020 was completed. Demographic, clinical, and outcome data were compared between infants with or without placental pathologic lesions.

resultsIn this cohort, 59/107 (55%) infants had medical NEC, and 48 (45%) had surgical NEC. The infants had a mean gestational age of 28.1±3.7 weeks and a birth weight of 1103±647 g. Maternal vascular malperfusion (82/107, 76.6%) and acute histological chorioamnionitis (42, 39.3%) were the most common pathological placental lesions. Acute histologic chorioamnionitis with fetal inflammatory response was more common in infants with surgical NEC vs. medical NEC (35.4% vs. 15.3%; p = 0.02). The NEC Infants with WMI on brain MRI scans had a significantly higher incidence of acute histological chorioamnionitis (52% vs. 27.8%; P = 0.04). No significant differences in mortality, length of stay and postoperative outcomes in neonates with and without acute histologic chorioamnionitis with fetal inflammatory response were noted. On unadjusted logistic regression, acute histologic chorioamnionitis without fetal inflammatory response was also associated with higher odds of WMI (OR 2.81; 95% CI 1.05-7.54; p = 0.039).

conclusionAcute histological chorioamnionitis without fetal inflammatory response was associated with higher odds of WMI in infants with NEC, with no significant impact on mortality and other postoperative outcomes.

Indexed as

Brain InjuriesChorioamnionitisEnterocolitis, NecrotizingFetal DiseasesInfant, Newborn, DiseasesWhite MatterFemaleHumansInfantInfant, NewbornInfant, PrematurePlacentaPregnancyRetrospective StudiesNecrotizing enterocolitisplacental pathologypreterm infantswhite matter injury

Identifiers

PMID36744350
PMCPMC10278122
OpenAlexW4319073668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.