Evidence map›Paper›PMID 36744144›Full record

ArticleFrontiers in medicine2023

Torque Teno virus DNA is found in the intracranial aneurysm wall-Is there a causative role?

Nícollas Nunes Rabelo, Marcia Harumy Yoshikawa, João Paulo Mota Telles, Giselle Coelho, Caio Santos de Souza, Natan Ponzoni Galvani de Oliveira, Tania Regina Tozetto Mendoza, Paulo Henrique Braz-Silva, Antonio Luiz Boechat, Manoel Jacobsen Teixeira and 1 more

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In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nícollas Nunes RabeloDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
Marcia Harumy YoshikawaDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
João Paulo Mota TellesDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
Giselle CoelhoDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
Caio Santos de SouzaLaboratory of Virology (LIM-52), University of São Paulo, São Paulo, SP, Brazil.
Natan Ponzoni Galvani de OliveiraLaboratory of Virology (LIM-52), University of São Paulo, São Paulo, SP, Brazil.
Tania Regina Tozetto MendozaLaboratory of Virology (LIM-52), University of São Paulo, São Paulo, SP, Brazil.
Paulo Henrique Braz-SilvaLaboratory of Virology (LIM-52), University of São Paulo, São Paulo, SP, Brazil.
Antonio Luiz BoechatDepartment of Parasitology, Federal University of Amazonas, Manaus, AM, Brazil.
Manoel Jacobsen TeixeiraDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
Eberval Gadelha FigueiredoDepartment of Neurosurgery, University of São Paulo, São Paulo, SP, Brazil.
Universidade de São Paulo · BRUniversidade Federal do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Torque Teno virus (TTV) is a recently discovered virus with high prevalence worldwide, that has been associated with vascular diseases. The aim of this study is to investigate the prevalence of TTV molecular DNA in the intracranial aneurysm (IA) artery walls. Method: Samples of IA walls were collected after microsurgical clipping from 35 patients with IA (22 ruptured/13 unruptured cases). The samples were submitted to molecular DNA extraction using the Results: TTV was detected in 15 (42.85%) cases, being 10 (45.4%) ruptured and 5 (38.4%) unruptured ( Conclusion: This study demonstrated a relatively high prevalence of viral DNA in the walls of IAs. This is the first study to identify the presence of TTV DNA in IA's samples, which was found more often in ruptured lesions. This is an exploratory study, therefore, larger studies are required to clarify the relationships between inflammation, viral infection, IA formation and rupture.

Indexed as

biomarkerbrain aneurysmintracranial aneurysmmolecular virus DNATTVvirus

Identifiers

PMID36744144
PMCPMC9894622
OpenAlexW4317402482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.