Evidence map›Paper›PMID 36744021›Full record

ArticlePNAS nexus2023

Maternal nutritional status modifies heat-associated growth restriction in women with chronic malnutrition.

Kartik Shankar, Sumera A Ali, Meghan L Ruebel, Saleem Jessani, Sarah J Borengasser, Stephanie P Gilley, Puujee Jambal, Deaunabah N Yazza, Nicholas Weaver, Jennifer F Kemp and 6 more

Erratum issued Registry-linked trialAbstract read
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07489664 (Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07489664 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat

TypeinterventionalSponsorAga Khan UniversityRan2026 to 2028Enrolled292ConditionsHeat Stress, Pregnancy, Women of Reproductive Age, Nutrition StatusArmsIndigenous Balanced Diet Arm
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Dual challenges, shared wins: unlocking climate financing for nutrition.International journal for equity in health · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kartik ShankarDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0002-7964-9026
Sumera A AliAga Khan University, Karachi 7480​0, Pakistan.
Meghan L RuebelDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Saleem JessaniAga Khan University, Karachi 7480​0, Pakistan.
Sarah J BorengasserDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Stephanie P GilleyDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Puujee JambalDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Deaunabah N YazzaDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Nicholas WeaverDepartment of Mathematical and Statistical Sciences, University of Colorado Denver, CO 80204, USA.
Jennifer F KempDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Jamie L WestcottDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Audrey E HendricksDepartment of Mathematical and Statistical Sciences, University of Colorado Denver, CO 80204, USA.
Sarah SaleemAga Khan University, Karachi 7480​0, Pakistan.
Robert L GoldenbergDepartment of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA.
K Michael HambidgeDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Nancy F KrebsDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
NIDDK National Research Service Award (NRSA) T32 Diversity Administrative SupplementT32DK007658 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Kristen Elizabeth Boyle, Ihuoma U Eneli · 1991 to 2026
$6.0M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
The Global Network and Preconception Maternal NutritionU10HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI HAMBIDGE, K MICHAEL, KREBS, NANCY F · 2013 to 2017
$5.1M
Triglycerides as a Predictor of Newborn Subcutaneous and Liver Fat: Contributors to Fetal Fat Accretion in Obese PregnanciesR01HD102726 · NICHD · UNIVERSITY OF COLORADO DENVER · PI LINDA Anne BARBOUR, Teri L Hernandez · 2021 to 2026
$3.2M
Preconception Maternal Nutrition, Offspring DNA Methylation, and InfantGrowth in Low Resource SettingsR01HD110585 · NICHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Sarah Jean Borengasser · 2023 to 2026
$2.2M
Maternal obesity, micronutrient supplementation, and epigenetic programmingK01DK109077 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BORENGASSER, SARAH JEAN · 2016 to 2018
$403k
NICHD NIH HHS R01 HD102726NICHD NIH HHS R01 HD110585NICHD NIH HHS U10 HD076474NICHD NIH HHS UG1 HD076474NIDDK NIH HHS K01 DK109077NIDDK NIH HHS P30 DK048520NIDDK NIH HHS T32 DK007658
6 · The paper itself

Abstract

Rapid changes in the global climate are deepening existing health disparities from resource scarcity and malnutrition. Rising ambient temperatures represent an imminent risk to pregnant women and infants. Both maternal malnutrition and heat stress during pregnancy contribute to poor fetal growth, the leading cause of diminished child development in low-resource settings. However, studies explicitly examining interactions between these two important environmental factors are lacking. We leveraged maternal and neonatal anthropometry data from a randomized controlled trial focused on improving preconception maternal nutrition (Women First Preconception Nutrition trial) conducted in Thatta, Pakistan, where both nutritional deficits and heat stress are prevalent. Multiple linear regression of ambient temperature and neonatal anthropometry at birth (

Indexed as

climate changegrowth restrictionheat stressmalnutritionpregnancy

Identifiers

PMID36744021
PMCPMC9896899

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.