Evidence map›Paper›PMID 36744010›Full record

ArticleBrain communications2023

Investigating the factors that explain white matter hyperintensity load in older Indians.

Leon Aksman, Kirsten Lynch, Arthur Toga, Aparajit Ballav Dey, Jinkook Lee

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Leon AksmanMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0003-2342-0780
Kirsten LynchMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0003-3976-5783
Arthur TogaMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Aparajit Ballav DeyGeriatric Medicine, All India Institute of Medical Sciences, New Delhi, Delhi 110029, India.
Jinkook LeeDana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA.
University of Southern California · USAll India Institute of Medical Sciences · IN

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG051125
6 · The paper itself

Abstract

White matter hyperintensities are areas of hyperintense signal on MRI that typically represent cerebrovascular pathology. While focal white matter hyperintensities are common among older individuals, extensive white matter hyperintensities have been found to accelerate the progression of dementia. However, little is currently known about how various socioeconomic, health, lifestyle and environmental factors affect the severity of these lesions, particularly in low- and middle-income countries such as India. We investigated this question using cross-sectional MRI data (

Indexed as

cerebrovascular pathologydementia risk factorslow- and middle-income countriesMRIwhite matter hyperintensities

Identifiers

PMID36744010
PMCPMC9891346
OpenAlexW4317214967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.