Evidence map›Paper›PMID 36744002›Full record

ArticleFrontiers in cellular neuroscience2023

Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons.

Giulia Tomagra, Claudio Franchino, Federico Cesano, Giovanni Chiarion, Antonio de Iure, Emilio Carbone, Paolo Calabresi, Luca Mesin, Barbara Picconi, Andrea Marcantoni and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Featured Papers in Computer Methods in Biomedicine.Bioengineering (Basel, Switzerland) · 2024
    Article
  3. Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Giulia TomagraDrug Science Department, University of Torino, Turin, Italy.
Claudio FranchinoDrug Science Department, University of Torino, Turin, Italy.
Federico CesanoNanostructured Interfaces and Surfaces Inter-Departmental Research Centre, Turin, Italy.
Giovanni ChiarionMathematical Biology and Physiology, Department of Electronics and Telecommunications, Turin, Italy.
Antonio de IureLaboratory Experimental Neurophysiology, IRCCS San Raffaele Rome, Rome, Italy.
Emilio CarboneDrug Science Department, University of Torino, Turin, Italy.
Paolo CalabresiNeurological Clinic, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Luca MesinMathematical Biology and Physiology, Department of Electronics and Telecommunications, Turin, Italy.
Barbara PicconiLaboratory Experimental Neurophysiology, IRCCS San Raffaele Rome, Rome, Italy.
Andrea MarcantoniDrug Science Department, University of Torino, Turin, Italy.
Valentina CarabelliDrug Science Department, University of Torino, Turin, Italy.
University of Turin · ITInstitute of Electronics, Computer and Telecommunication Engineering · ITAgostino Gemelli University Polyclinic · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleNational Interuniversity Consortium of Materials Science and Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to monitor the effects of extracellular α-synuclein on the firing activity of midbrain neurons dissociated from substantia nigra TH-GFP mice embryos and cultured on microelectrode arrays (MEA). We monitored the spontaneous firing discharge of the network for 21 days after plating and the role of glutamatergic and GABAergic inputs in regulating burst generation and network synchronism. Addition of GABA

Indexed as

alpha-synucleinMaximum of the Absolute Value of the Cross-Correlation (MAVCC)midbrain dopamine neuronmulti-electrodes arrays (MEA)spontaneous firing activity

Identifiers

PMID36744002
PMCPMC9896582
OpenAlexW4317539293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.