Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?

Khaled Mohey El-Din Monib, Neveen Emad Sorour, Naglaa Fathy Alhusseini, Asmaa Gaber Abdou, Amal Yousif, Rehab Mohammed Salem

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Article in The Journal of clinical and aesthetic dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors at 2 institutions in 1 country.

Khaled Mohey El-Din MonibDrs. Monib and Sorour are Professors of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt.

Neveen Emad SorourDrs. Monib and Sorour are Professors of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt.

Naglaa Fathy AlhusseiniDr. Alhusseini is a Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine at Benha University in Benha, Egypt.

Asmaa Gaber AbdouDr. Abdou is a Professor of Pathology, Faculty of Medicine at Menoufia University, Egypt.

Amal YousifDr. Yousif is a Lecturer of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt.

Rehab Mohammed SalemDr. Salem is an Assistant Professor of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt.

Benha University · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The search for objective factors that help in predicting the response of vitiligo treatment is very important. Objective: We sought to evaluate the effect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV). Methods: This prospective clinical trial included 50 NSV patients and 50 healthy control subjects. α-MSH tissue levels as well as MITF and IDH2 immunostaining were assessed in normal and vitiliginous skin biopsies before treatment and then in the repigmented areas following 24 NB-UVB phototherapy treatment sessions using ELISA technique and immunohistochemical study, respectively. Results: There was a significant negative correlation between baseline VASI scores and the tissue levels of α-MSH ( Conclusion: α-MSH- MIFT axis and the antioxidant protein IDH2 are promising objective markers of non-segmental vitiligo severity, and are suggested as predictors of vitiligo response to treatment.

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PMID36743971

PMCPMC9891215

OpenAlexW4319293971

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