Evidence map›Paper›PMID 36743937›Full record

SynthesisFrontiers in endocrinology2022

The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose-response meta-analysis.

Qin Ling, Jiawei Chen, Xiao Liu, Yi Xu, Jianyong Ma, Peng Yu, Kai Zheng, Fuwei Liu, Jun Luo

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07513922 (Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver Fibrosis), which is not on this map. Cited by 47 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07513922 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver Fibrosis

Typeobservational_patient_registrySponsorAssiut UniversityRan2026 to 2027Enrolled96ConditionsLiver FibrosisArms• Fasting triglycerides (TG) • Fasting plasma glucose • High-sensitivity C-reactive protein (hs-CRP) • Liver enzymes (ALT, AST, GGT) • Platelet count • HbA1c • Lipid profile (total cholesterol, HDL-C,
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  11. [Causal relationship between the triglycerideZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qin LingDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.
Jiawei ChenDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.
Xiao LiuDepartment of Cardiology, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Yi XuDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.
Jianyong MaDepartment of Pharmacology and Systems Physiology, University of Cinnati College of Medicine, Cincinnati, OH, United States.
Peng YuDepartment of Endocrine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Kai ZhengMedical Care Strategic Customer Department, China Merchants Bank Shenzhen Branch, Shenzhen, China.
Fuwei LiuDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.
Jun LuoDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose-response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose-response association between the TyG index and the risk of NAFLD. Methods: We systematically searched the Cochrane Library, PubMed, and Embase databases until July 2022 for relevant studies. The robust error meta-regression method was used to investigate the dose-response association between the TyG index and NAFLD. Summary relative risks (ORs) and 95% CIs were estimated by using a random-effects model. Results: A total of 4 cohort and 8 cross-sectional studies were included, with 28,788 NAFLD cases among the 105,365 participants. A positive association for the risk of NAFLD was observed for each additional unit of the TyG index with a linear association (p=0.82), and the summary OR was 2.84 (95% CI, 2.01-4.01). In the subgroup analyses, a stronger association of the TyG index with NAFLD was shown in females than in males (men: OR=2.97, 95% CI 2.55-3.46, women: OR=4.80, 95% CI 3.90-5.90, P Conclusion: The TyG index may be a novel independent risk factor for NAFLD beyond traditional risk factors. Systematic Review Registration: https://www.crd.york.ac.uk/prospero, identifier (CRD42022347813).

Indexed as

Non-alcoholic Fatty Liver DiseaseCross-Sectional StudiesFemaleGlucoseHumansMaleRisk FactorsTriglyceridesGlucoseTriglyceridesdose-responsemeta-analysisnonalcoholic fatty liver diseaseprognosistriglyceride and glucose index

Identifiers

PMID36743937
PMCPMC9892833

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.