SynthesisFrontiers in endocrinology2022
Local symptoms of Hashimoto's thyroiditis: A systematic review.
Synthesis in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Association Between the Levothyroxine Therapy and the Levels of Anti-Thyroid Antibodies in Women with Hypothyroidism Due to Hashimoto's Thyroiditis-Narrative Review.International journal of molecular sciences · 2026Review
- Carotidynia-A Rare Cause of Anterior Neck Pain: Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Effectiveness and Safety of Kangjia Decoction Granules for the Treatment of Hashimoto Thyroiditis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial.JMIR research protocols · 2026Article
- Heterozygous pathogenic variants inOpen life sciences · 2026Article
- Immunopathogenesis, Diagnosis, and Treatment of Hashimoto's Thyroiditis.Archives of internal medicine research · 2026Article
- Hashimoto's Thyroiditis with Subclinical Hypothyroidism and Multi-System Symptoms: A Case of a Middle-Aged Male.International medical case reports journal · 2026Article
- Lactoferrin alleviates oxidative stress and endoplasmic reticulum stress induced by autoimmune thyroiditis by modulating the mTOR pathway in the thyroid.Journal of endocrinological investigation · 2025Article
- No Association Between Diet Quality, Nutritional Status, and Quality of Life in Women with Hashimoto's Thyroiditis-A Cross-Sectional Study.Nutrients · 2025Article
- Potential common mechanisms between primary Sjögren's syndrome and Hashimoto's thyroiditis: a public databases-based study.Frontiers in genetics · 2025Article
- Thyroid antibodies in Hashimoto's thyroiditis patients are positively associated with inflammation and multiple symptoms.Scientific reports · 2024Article
- Traditional Chinese Medicine for Hashimoto's Thyroiditis: Focus on Selenium and Antioxidant Phytochemicals.Antioxidants (Basel, Switzerland) · 2024Review
- The Role of the Immune System in the Course of Hashimoto's Thyroiditis: The Current State of Knowledge.International journal of molecular sciences · 2024Review
- The Resolution of Obstructive Sleep Apnea in a Patient with Goiter after Total Thyroidectomy: A Case Report.Reports (MDPI) · 2024Article
- A COMPREHENSIVE EVALUATION OF HEMOGRAM-DERIVED INFLAMMATORY INDICES IN HASHIMOTO THYROIDITIS AND NON-IMMUNOGENIC HYPOTHYROIDISM.Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Hashimoto's thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence. Methods: A systematic review was performed to find articles in PubMed that discuss the local symptoms of HT. Relevant vocabulary terms and key terms included: autoimmune thyroid disease (AITD), hyperthyroidism, hypothyroidism, neck, throat, pharynx, airway, esophagus, breathe, swallow, globus, sleep apnea, symptoms, and quality of life. Two investigators independently screened the eligible studies. Results: A total of 54 articles fulfilled the inclusion criteria. Of these, 25 were clinical studies, 24 were case reports, and five were reviews. These clinical studies and case reports included a total of 2660 HT patients. There were eight local symptoms related to HT: neck pain (0.02%~16%), voice changes (7%~30%), throat discomfort (20%~43.7%), shortness of breath (28%~50%), dysphagia (29%), goiter-related symptoms (69.44%), sleep apnea, and generally defined compressive symptoms. Due to the use of different outcome measures among all the studies, a meta-analysis of the data could not be performed. Conclusion: Goiter symptoms, which are an item on the ThyPRO scales, are the most frequent local symptoms in HT patients, and include neck pain, voice changes, throat discomfort, and dysphagia. These local symptoms should be identified in the clinic and included in the early diagnosis and management of HT, as well as evaluated further to understand their relevance in the pathogenesis of HT.
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