Evidence map›Paper›PMID 36743674›Full record

ReviewFrontiers in medicine2022

Aerosol delivery through high-flow nasal therapy: Technical issues and clinical benefits.

Cecilia Calabrese, Anna Annunziata, Domenica Francesca Mariniello, Valentino Allocca, Pasquale Imitazione, Rosa Cauteruccio, Francesca Simioli, Giuseppe Fiorentino

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06815679 (The Physiological Effects of Nebulized Salbutamol in Patients With Acute Respiratory Failure During HFNC), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06815679 phase2 / phase3not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Physiological Effects of Nebulized Salbutamol in Patients With Acute Respiratory Failure During HFNC

TypeinterventionalSponsorUniversità degli Studi di FerraraRan2025 to 2026Enrolled20ConditionsAcute Respiratory Failure, PneumoniaArmssalbutamol 2.5 mg via vibrating mesh nebulizer (VMN)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. High-flow nasal cannula in severe asthma exacerbations: current evidence and clinical perspectives.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cecilia CalabreseDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Anna AnnunziataDepartment of Intensive Care, Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Domenica Francesca MarinielloDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Valentino AlloccaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Pasquale ImitazioneDepartment of Intensive Care, Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Rosa CauteruccioDepartment of Intensive Care, Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Francesca SimioliDepartment of Intensive Care, Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Giuseppe FiorentinoDepartment of Intensive Care, Azienda Ospedaliera di Rilievo Nazionale dei Colli, Naples, Italy.
Azienda di Rilievo Nazionale ed Alta Specializzazione · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-flow nasal cannula (HFNC) therapy is an oxygen delivery method particularly used in patients affected by hypoxemic respiratory failure. In comparison with the conventional "low flow" oxygen delivery systems, it showed several important clinical benefits. The possibility to nebulize drugs

Indexed as

aerosol–therapeuticbronchodilatorsHFNChigh-flow nasal cannulajet nebulizervibrating mesh nebulizer

Identifiers

PMID36743674
PMCPMC9889634
OpenAlexW4317036953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.