ArticleFrontiers in cell and developmental biology2023
Systemic inflammatory regulators and risk of acute-on-chronic liver failure: A bidirectional mendelian-randomization study.
Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.BMC gastroenterology · 2024Pooled it
- Association between comorbidity and chronic obstructive pulmonary disease: a systematic review and meta-analysis of Mendelian randomization studies.Therapeutic advances in respiratory diseasePooled it
- The Effects of Physical Activity on Functional Dyspepsia: A Mendelian Randomization and Randomized Controlled Study.Journal of neurogastroenterology and motility · 2026Article
- Article
- The Association Between Physical Activity and Epigastric Pain: A Mendelian Randomization and Cross-Sectional Study.Pain research & management · 2026Article
- Multifaceted mechanistic exploration ofFrontiers in cell and developmental biology · 2026Article
- Integrated Metagenomic and Metabolomic Analyses Reveal a Microbiota-Metabolite Axis Associated with Gallstone Pathogenesis.Metabolites · 2025Article
- Study on the prediction of prognosis of patients with acute liver failure treated with artificial liver by serum NLR and IL-6 levels.Journal of medical biochemistry · 2025Article
- Thyroid dysfunction and pulmonary arterial hypertension: A bidirectional mendelian randomization study.International journal of cardiology. Heart & vasculature · 2025Article
- Moderate and severe depression increase the incidence of cholelithiasis: Results from Mendelian randomization study and the NHANES 2017-March 2020.Social psychiatry and psychiatric epidemiology · 2025Observational
- [Two-sample Mendelian randomization analysis for the causal relationship between 91 circulating inflammatory proteins and liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Article
- Causal relationship between nitrogen dioxide and the risk of Parkinson's disease: Evidence from a Mendelian randomization study.Medicine · 2025Article
- Therapeutic potential of GLP-1RAs in sleep apnea with genetic associations to type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Tryptophan-Derived Metabolites and Glutamate Dynamics in Fatal Insulin Poisoning: Mendelian Randomization of Human Cohorts and Experimental Validation in Rat Models.International journal of molecular sciences · 2025Article
- Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis.AMB Express · 2025Article
- Causal Effects of Circulating Micronutrients on Cognitive Function: Evidence From a Mendelian Randomization Study.Brain and behavior · 2025Article
- Associations Between Gut Microbiota and Diabetic Nephropathy: A Mendelian Randomization Study.Aging medicine (Milton (N.S.W)) · 2025Article
- Multidimensional Analysis of Frailty and Its Influencing Factors in Hospitalized Elderly Stroke Patients.Clinical interventions in aging · 2025Article
- Exploring the Relationship Between 91 Inflammatory Cytokines and IgA Nephropathy Using a Two-Sample Mendelian Randomization Study and the Gene Expression Omnibus Database.Mediators of inflammation · 2025Article
- Association of branched-chain amino acids and risk of three urologic cancers: a Mendelian randomization study.Translational cancer research · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation plays a role in the pathogenesis of acute-on-chronic liver failure (ACLF), however, whether there is a causal relationship between inflammation and ACLF remains unclear. A two-sample Mendelian randomization (MR) approach was used to investigate the causal relationship between systemic inflammatory regulators and ACLF. The study analyzed 41 cytokines and growth factors from 8,293 individuals extracted from a genome-wide association study (GWAS) meta-analysis database involving 253 ACLF cases and 456,095 controls. Our results showed that lower stem cell factor (SCF) levels, lower basic fibroblast growth factor (bFGF) levels and higher Interleukin-13 (IL-13) levels were associated with an increased risk of ACLF (OR = 0.486, 95% CI = 0.264-0.892,
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