Evidence map›Paper›PMID 36743309›Full record

ArticleFrontiers in cellular and infection microbiology2023

Antimicrobial resistance profile of methicillin-resistant

Xia Wu, Chuanqing Wang, Leiyan He, Hongmei Xu, Chunmei Jing, Yinghu Chen, Aiwei Lin, Jikui Deng, Qing Cao, Huiling Deng and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  8. Clinical Features and Antibiotic Susceptibility ofJournal of clinical medicine · 2025
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  13. A Novel Bacitracin-like Peptide from Mangrove-IsolatedAntibiotics (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Lincosamide monotherapy treatment of methicillin-resistant Staphylococcus aureus pneumonia in tropical Australia: a case series.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Xia WuDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.
Chuanqing WangDepartment of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, China.
Leiyan HeDepartment of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, China.
Hongmei XuDepartment of Infectious Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chunmei JingDepartment of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China.
Yinghu ChenDepartment of Infectious Diseases, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Aiwei LinDepartment of Infectious Diseases, Qilu Children's Hospital of Shandong University, Jinan, China.
Jikui DengDepartment of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
Qing CaoDepartment of Infectious Diseases, Shanghai Children's Medical Center of Shanghai Jiaotong University School of Medicine, Shanghai, China.
Huiling DengDepartment of Infectious Diseases, Xi'an Children's Hospital, Xi'an, China.
Huijun CaiDepartment of Clinical Laboratory, Xi'an Children's Hospital, Xi'an, China.
Yiping ChenDepartment of Pediatric Infectious Diseases, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Jinhong YangDepartment of Clinical Laboratory, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Ting ZhangDepartment of Gastroenterology and Infectious Diseases, Children's Hospital of Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yuanyuan HuangDepartment of Pediatrics, Bethune First Hospital of Jilin University, Changchun, China.
Jianhua HaoDepartment of Infectious Diseases, Kaifeng Children's Hospital, Kaifeng, China.
Hui YuDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNXi’an Children’s Hospital · CNChildren's Hospital of Chongqing Medical University · CNChongqing Medical University · CNFirst Bethune Hospital of Jilin University · CNKaifeng City Children's Hospital · CNQilu Hospital of Shandong University · CNShanghai Children's Hospital · CNShanghai Children's Medical Center · CNShenzhen Children's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methicillin-resistant Methods: This retrospective study was conducted from January 2016-December 2021 on patients at eleven ISPED-group hospitals. Results: From 2016-2021, a total of 13024 MRSA isolates were obtained from children. The most common age group for patients with MRSA infection was less than 3 years old, and newborns were an important group affected by MRSA infection. MRSA was most commonly isolated from the lower respiratory, an abscess, a secretion, or blood in neonates and from the lower respiratory, an abscess, or the upper respiratory in non-neonates. All isolates were susceptible to vancomycin and linezolid and resistant to penicillin; additionally, 76.88%, 54.97%, 22.30%, 5.67%, 5.14%, 3.63%, and 1.42% were resistant to erythromycin, clindamycin, tetracycline, levofloxacin, sulfamethoxazole-trimethoprim (TMP-SMX), gentamicin, and rifampin, respectively. Between 2016 and 2021, a significant increase was seen in the levofloxacin- and TMP-SMX-resistance rates (from 5.45% to 7.14% and from 4.67% to 6.50%, respectively) among MRSA isolates, along with a significant decrease in the rates of resistance to erythromycin (from 82.61% to 68.08%), clindamycin (from 60.95% to 46.82%), tetracycline (from 25.37% to 17.13%), gentamicin (from 4.53% to 2.82%), and rifampin (from 1.89% to 0.41%). Discussion: The antibiotic-resistance rates varied among MRSA isolated from different sources. Because of the high antibiotic resistance rate to clindamycin, this antibiotic is not recommended for empirical treatment of MRSA infections, especially in osteomyelitis.

Indexed as

Communicable DiseasesMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAbscessAnti-Bacterial AgentsChildChild, PreschoolClindamycinDrug Resistance, BacterialErythromycinGentamicinsHumansInfant, NewbornLevofloxacinMicrobial Sensitivity TestsRetrospective StudiesAnti-Bacterial AgentsClindamycinErythromycinGentamicinsLevofloxacinRifampinTetracyclineTrimethoprim, Sulfamethoxazole Drug Combinationantimicrobial resistancechildreninfectious disease surveillance of pediatrics (ISPED)methicillin-resistant Staphylococcus aureusneonates

Identifiers

PMID36743309
PMCPMC9892648
OpenAlexW4319293923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.