Evidence map›Paper›PMID 36743305›Full record

ArticleFrontiers in cellular and infection microbiology2023

Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of

Rafaella de Miranda Villarim Meira, Sara Lins da Silva Gomes, Edgar Schaeffer, Thayssa Da Silva, Andréia Carolinne de Souza Brito, Larissa Moreira Siqueira, Job Domingos Inácio, Elmo Eduardo Almeida-Amaral, Alda Maria Da-Cruz, Milla Bezerra-Paiva and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Rafaella de Miranda Villarim MeiraLaboratório de Imunofarmacologia Parasitária, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Sara Lins da Silva GomesLaboratório de Catálise Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Edgar SchaefferLaboratório de Catálise Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Thayssa Da SilvaLaboratório de Imunofarmacologia Parasitária, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Andréia Carolinne de Souza BritoLaboratório de Imunofarmacologia Parasitária, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Larissa Moreira SiqueiraLaboratório de Imunofarmacologia Parasitária, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Job Domingos InácioLaboratório de Bioquímica de Tripanosomatídeos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Elmo Eduardo Almeida-AmaralLaboratório de Bioquímica de Tripanosomatídeos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Alda Maria Da-CruzDisciplina de Parasitologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Milla Bezerra-PaivaLaboratório Interdisciplinar de Pesquisas Médicas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Renata Heisler NevesLaboratório de Helmintologia Romero Lascasas Porto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana Silva RodriguesLaboratório de Imunopatologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Patricia Maria Lourenço DutraLaboratório de Imunologia do Exercício, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Paulo Roberto Ribeiro CostaLaboratório de Química Bioorgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Alcides José Monteiro da SilvaLaboratório de Catálise Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Silvia Amaral Gonçalves Da-SilvaLaboratório de Imunofarmacologia Parasitária, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Universidade do Estado do Rio de Janeiro · BRUniversidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapeutic ways adopted for the treatment of leishmaniasis are toxic and expensive including parasite resistance is a growing problem. Given this scenario, it is urgent to explore treatment alternatives for leishmaniasis. The aim of this study was to evaluate the effect of 3-phenyl-lawsone (3-PL) naphthoquinone on

Indexed as

Antiprotozoal AgentsLeishmania braziliensisLeishmaniasis, CutaneousNaphthoquinonesTattooingAnimalsCricetinaeMeglumine AntimoniateParasite LoadAntiprotozoal AgentslawsoneMeglumine AntimoniateNaphthoquinones3-phenyl-lawsonechemotherapyhamster-modelLeishmania (Viannia) braziliensissubcutaneoustattooing

Identifiers

PMID36743305
PMCPMC9892647
OpenAlexW4319293850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.