Evidence map›Paper›PMID 36742346›Full record

ArticleCardiopulmonary physical therapy journal2023

Cardiorespiratory Insufficiency and Performance Fatigability in Women with Systemic Lupus Erythematosus.

Liana C Wooten, Sarfaraz Hasni, Jamal A Mikdashi, Randall E Keyser

Open access · greenAbstract read
In one paragraph

Article in Cardiopulmonary physical therapy journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. VOLupus · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Liana C WootenTufts University, Department of Public Health and Community Medicine, Division of Doctorate of Physical Therapy (DPT), Phoenix, Arizona.
Sarfaraz HasniNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD.
Jamal A MikdashiDepartment of Medicine, Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD.
Randall E KeyserDepartment of Rehabilitation Science, College of Health and Human Services, George Mason University, Fairfax, VA.
George Mason University · USNational Institutes of Health · USTufts University · USUniversity of Maryland, Baltimore · US

Funding

Disability and Aerobic Capacity in SLER03HD039775 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI KEYSER, RANDALL E · 2001 to 2002
$149k
NICHD NIH HHS R03 HD039775
6 · The paper itself

Abstract

Purpose: Patients with systemic lupus erythematosus (SLE) experience excessive, debilitating fatigue with previously reported evidence of etiologically mediated cardiorespiratory impairments. Performance fatigability provides a precise characterization of fatigue as it can be quantified objectively as a function of time, frequency, and/or duration. Nevertheless, little consideration has been given to understanding performance fatigability and its physiological determinants in those with SLE. The purpose of this study was to characterize performance fatigability in patients with SLE, utilizing measures surrounding the anaerobic threshold, with emphasis on cardiorespiratory impairment as a potential mediating factor. Methods: This was a case-control study design. 44 physically inactive women, 26 with SLE and 18 controls, completed a treadmill cardiopulmonary exercise test to volitional exhaustion. Results: There were no significant differences in age (SLE 34.8(9.0) vs Control 36.9(7.3) yrs; p=0.422) between groups. BMI (SLE 27.1(5.4) vs Control 23.8(5.2) kg/m Conclusion: This study underscores severe performance fatigability in patients with SLE and its link to cardiorespiratory insufficiency. Physiological presentation of performance fatigability was observed during very low intensities of exercise, emphasizing the negative impact it may have on physical function in this population.

Indexed as

Anaerobic ThresholdExerciseFatigabilityPhysical ActivitySLE

Identifiers

PMID36742346
PMCPMC9897569
OpenAlexW4285084783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.