Evidence map›Paper›PMID 36742280›Full record

ArticleDEN open2023

Local recurrence of submucosal invasive colorectal cancer after endoscopic submucosal dissection revealed by copy number variation.

Yu Okazawa, Kiichi Sugimoto, Yuki Ii, Takahiro Irie, Megumi Kawaguchi, Aya Kobari, Hirotaka Momose, Yuki Tsuchiya, Kota Amemiya, Shunsuke Motegi and 17 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in DEN open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 1 country.

Yu OkazawaDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0001-8550-8804
Kiichi SugimotoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Yuki IiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Takahiro IrieDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Megumi KawaguchiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Aya KobariDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Hirotaka MomoseDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Yuki TsuchiyaDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Kota AmemiyaDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Shunsuke MotegiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Ryoichi TsukamotoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Kazumasa KureDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Kumpei HonjoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Hisashi RoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Rina TakahashiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Shingo KawanoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Masaya KawaiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Shun IshiyamaDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Makoto TakahashiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Yutaka KojimaDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Yuichi TomikiDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Atsushi ArakawaDepartment of Human Pathology Juntendo University Faculty of Medicine Tokyo Japan.
Takashi YaoDepartment of Human Pathology Juntendo University Faculty of Medicine Tokyo Japan.
Kaishi SatomiDepartment of Pathology, Kyorin University School of Medicine Tokyo Japan.
Yuko MatsushitaDepartment of Brain Disease Translational Research Faculty of Medicine Juntendo University Tokyo Japan.
Koichi IchimuraDepartment of Brain Disease Translational Research Faculty of Medicine Juntendo University Tokyo Japan.
Kazuhiro SakamotoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Juntendo University · JPKyorin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case in which analysis of copy number variation revealed local recurrence of submucosal invasive colorectal cancer after curative endoscopic submucosal dissection (ESD). An 86-year-old man with a history of abdominoperineal resection of the rectum for rectal cancer underwent resection with ESD for early-stage sigmoid cancer 5 cm away from the stoma opening. At the same time, ileocecal resection was performed for advanced cecal cancer. Twelve months after ESD, advanced cancer occurred in the area of the ESD lesion. It was unclear if the cancer was a local recurrence after ESD, implantation of cecal cancer, or a new lesion. Copy number variation analysis performed for the three lesions revealed that the new lesion originated from residual tumor cells from ESD and was unlikely to be cecal cancer.

Indexed as

cecal cancercopy number variationendoscopic submucosal dissectionlocal recurrencesubmucosal invasive colorectal cancer

Identifiers

PMID36742280
PMCPMC9889967
OpenAlexW4319294681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.