Evidence map›Paper›PMID 36742278›Full record

ArticleAmerican journal of blood research2022

A comprehensive analysis of cytogenetics, molecular profile, and survival among pediatric acute myeloid leukemia: a prospective study from a tertiary referral center.

Jagdish Prasad Meena, Harshita Makkar, Aditya Kumar Gupta, Sameer Bakhshi, Ritu Gupta, Deepshi Thakral, Anita Chopra, Pranay Tanwar, Ashish Datt Upadhyay, Nivedita Pathak and 1 more

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Article in American journal of blood research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jagdish Prasad MeenaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
Harshita MakkarDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
Aditya Kumar GuptaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
Sameer BakhshiDepartment of Medical Oncology, Dr. B.R.A. IRCH, All India Institute of Medical Sciences New Delhi 110029, India.
Ritu GuptaLaboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences New Delhi 110029, India.
Deepshi ThakralLaboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences New Delhi 110029, India.
Anita ChopraLaboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences New Delhi 110029, India.
Pranay TanwarLaboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences New Delhi 110029, India.
Ashish Datt UpadhyayDepartment of Biostatistics, All India Institute of Medical Sciences New Delhi 110029, India.
Nivedita PathakDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
Rachna SethDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
All India Institute of Medical Sciences · INDR. B.R.A. Institute Rotary Cancer Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe objectives of this study were to investigate the cyto-molecular profile and survival of pediatric acute myeloid leukemia (AML).

methodsThis prospective study was carried out in a tertiary care hospital from October 2018 to December 2020. Karyotype and cytogenetics analyses were done to identify chromosomal aberrations in pediatric AML. The targeted molecular panel utilized the polymerase chain reaction (PCR), reverse transcription-polymerase chain reaction (RT-PCR), and fragment analysis.

resultsA total of 70 patients of AML with aged ≤18 years were enrolled in this study. The cytogenetic analyses revealed abnormal/recurrent cytogenetic abnormalities (CA) in 64.3% of patients and normal cytogenetics (CN) in 35.7% of patients. FAB M2 subtype showed frequent aberrant expression of the CD19 marker. CD7, CD11b, and CD36a were significantly present in the absence of molecular markers. Common chromosomal abnormalities were t(translocation) (8;21) (55%), monosomy/deletion 7 (13%), monosomal karyotype (5%) and complex karyotype (3%). The fusion transcripts

conclusionThe majority of patients had abnormal/recurrent cytogenetics abnormalities. FAB M2 subtype showed frequent aberrant expression of the CD19. The absence of molecular markers may suggest the presence of CD7, CD11b, and CD36a expression. The overall survival has increased considerably in LMIC.

Indexed as

Acute myeloid leukemiachildrencytogeneticskaryotypemolecularsurvival

Identifiers

PMID36742278
PMCPMC9890188
OpenAlexW4319294434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.