ArticleIranian journal of basic medical sciences2023
High-efficient synthesis of carbon quantum dots from orange pericarp as fluorescence turn-on probes for Ca
Article in Iranian journal of basic medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 12 citations in OpenAlex.
- Biomass-derived nitrogen-doped carbon quantum dot-embedded electrospun PVA/PVP seed coatings for the electrochemical monitoring of germination and stress responses inNanoscale advances · 2026Article
- Advances in quantum dot-based fluorescent biosensors for enzyme detection: mechanistic insights and applications in disease.Mikrochimica acta · 2026Review
- Understanding the Toxicity of Carbon Dots: The Role of Synthesis Variability, Surface Chemistry, and Biological Context.International journal of molecular sciences · 2026Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: In this work, we propose an efficient preparation process for the synthesis of natural carbon quantum dots (NCQDs) by the usage of orange pericarp as the carbon natural resource, which is performed through hydrothermal treatment and top-down approaches. Materials and Methods: The structural, morphological, average size, and optical properties of synthesized NCQDs were investigated via dynamic light scattering (DLS), transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), atomic force microscopy (AFM), field emission scanning electron microscope (FESEM), energy dispersive x-ray spectroscopy (EDX), ultraviolet-visible spectroscopy (UV-Vis), and fluorescence PL spectra. Results: The shape of obtained NCQDs was observed to be spherical in the results of TEM analysis with an average size of 6-7 nm which confirms NCQDs essence. The signs of a strong peak (absorption) at around 282 nm throughout the UV-vis spectrum have been detected. The provided FTIR spectroscopy confirmed the existence of functional groups above the NCQDs surface. Furthermore, the surface charge of -11 mV through the obtained zeta potential regarding the synthesized NCQDs has been identified. MTT assay on mouse colon carcinoma cells (C26) demonstrated the lack of any signs of toxicity in NCQDs. Conclusion: The obtained NCQDs contain high photo-stability, excellent PL activity, and efficient fluorescent emission based on excitation. The results of kinetic studies revealed the ability of NCQDs to inhibit trypsin activity in a non-competitive model, which qualifies them as potent inhibitors and quenchers of trypsin. It can be suggested that the synthesized NCQDs have the potential of functioning as a sustainable and eco-friendly source for various applications such as sensors for detecting Ca
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