ArticleFrontiers in human neuroscience2022
Aberrant resting-state regional activity in patients with postpartum depression.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Intrinsic regional brain activity differences and its relationship with neurotransmitter and gene expression in postpartum depression: a voxel-based meta-analysis.Psychological medicine · 2026Pooled it
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
- A Call to Integrate Measures of Environmental Context into Research on Maternal Brain Health.International journal of environmental research and public health · 2025Review
- Postpartum depression-associated localized neural dysfunction: a voxel-wise meta-analysis of amplitude and synchronization alterations in resting-state fMRI.Frontiers in psychiatry · 2025Review
- Bridging Neurobiological Insights and Clinical Biomarkers in Postpartum Depression: A Narrative Review.International journal of molecular sciences · 2024Review
- Structural and functional improvement of amygdala sub-regions in postpartum depression after acupuncture.Frontiers in human neuroscience · 2023Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Postpartum depression (PPD) is a common disorder with corresponding cognitive impairments such as depressed mood, memory deficits, poor concentration, and declining executive functions, but little is known about its underlying neuropathology. Method: A total of 28 patients with PPD and 29 healthy postpartum women were recruited. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed in the fourth week after delivery. Individual local activity of PPD patients was observed by regional homogeneity (ReHo) during resting state, and the ReHo value was computed as Kendall's coecient of concordance (KCC) and analyzed for differences between voxel groups. Correlations between ReHo values and clinical variables were also analyzed. Result: Compared with healthy postpartum women, patients with PPD exhibited significantly higher ReHo values in the left precuneus and right hippocampus. ReHo value was significantly lower in the left dorsolateral prefrontal cortex (dlPFC) and right insula. Furthermore, ReHo values within the dlPFC were negatively correlated with the Edinburgh PPD scale (EPDS) score. The functional connectivity (FC) of the right hippocampus to the left precuneus and left superior frontal gyrus (SFG) was stronger in patients with PPD than that in controls. Conclusion: The present study provided evidence of aberrant regional functional activity and connectivity within brain regions in PPD, and it may contribute to further understanding of the neuropathology underlying PPD.
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