Evidence map›Paper›PMID 36741741›Full record

ArticleResearch in autism spectrum disorders2023

Emotion Regulation and Executive Function: Associations with Depression and Anxiety in Autism.

Caitlin M Conner, Rebecca Elias, Isaac C Smith, Susan W White

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Research in autism spectrum disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06181864 (Emotional Regulation to Manage Anxiety and Anger in Individuals With Autism), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06181864 naunknown statusnot on this map

Emotional Regulation to Manage Anxiety and Anger in Individuals With Autism

TypeinterventionalSponsorIstituto per la Ricerca e l'Innovazione BiomedicaRan2023 to 2025Enrolled40ConditionsAutism, Autism Spectrum DisorderArmsNAO intervention, Traditional intervention
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024
    Review
  18. Article
  19. Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Caitlin M ConnerUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Rebecca EliasUniversity of Southern California, Los Angeles, CA.
Isaac C SmithUniversity of Connecticut School of Medicine, West Hartford, CT.
Susan W WhiteUniversity of Alabama, Tuscaloosa, AL.
Hartford Hospital · USUniversity of Alabama · USUniversity of Pittsburgh · USUniversity of Southern California · US

Funding

Investigating Social Competence in Youth with Autism: A Multisite RCTR01MH114906 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CORBETT, BLYTHE ANNE · 2018 to 2021
$3.0M
STEPS: Stepped Transition in Education Program for Students with ASDR34MH104337 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WHITE, SUSAN WILLIAMS · 2014 to 2016
$666k
NIMH NIH HHS R01 MH114906NIMH NIH HHS R34 MH104337
6 · The paper itself

Abstract

Background: Adolescents and young adults with autism spectrum disorder (ASD) are prone to experience co-occurring mental health conditions such as mood or anxiety disorders, as well as impairments in emotion regulation and executive functioning. However, little research has examined inter-relationships among these constructs, despite evidence of additional stressors and increased risk of internalizing disorders at this age, relative to non-autistic individuals. If either emotion regulation or executive functioning are shown to have patterns of association with mental health, this can inform mechanism-based intervention. Method: Fifty-seven autistic adolescents and adults (16-25 years) with ASD in a transition intervention completed questionnaires and clinician-administered measures at baseline. Analyses assessed whether executive functioning impairment, above and beyond emotion regulation impairment, were associated with depression and anxiety symptoms. Results: ASD characteristics, emotion regulation, anxiety, and depression were significantly correlated. ASD characteristics was a significant contributor to depression and emotion regulation impairments were significant contributors to anxiety and depression. Findings indicated that inhibition difficulties did not uniquely contribute to depression or anxiety above emotion regulation impairment. Difficulties in cognitive flexibility were associated with depression above and beyond ASD characteristics, IQ, and emotion regulation, but not associated with anxiety. Conclusions: Although preliminary, findings suggest that inflexibility and regulatory impairment should be considered in depression remediation approaches. Improving ER, on the other hand, may have broader transdiagnostic impact across both mood and anxiety symptoms in ASD.

Indexed as

anxietycognitive flexibilitydepressionemotion regulationexecutive functioninginhibition

Identifiers

PMID36741741
PMCPMC9897310
OpenAlexW4313828104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.