Evidence map›Paper›PMID 36741718›Full record

ArticleFrontiers in oncology2022

Combined iodine-125 seed strand, portal vein stent, transarterial chemoembolization, lenvatinib and anti-PD-1 antibodies therapy for hepatocellular carcinoma and Vp4 portal vein tumor thrombus: A propensity-score analysis.

Zi-Han Zhang, Si-Nan Hou, Jia-Ze Yu, Wen Zhang, Jing-Qin Ma, Min-Jie Yang, Qing-Xin Liu, Ling-Xiao Liu, Jian-Jun Luo, Xu-Dong Qu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Clinical and translational radiation oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zi-Han ZhangDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Si-Nan HouDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Jia-Ze YuDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Wen ZhangDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Jing-Qin MaDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Min-Jie YangDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Qing-Xin LiuDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Ling-Xiao LiuDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Jian-Jun LuoDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Xu-Dong QuDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Zhi-Ping YanDepartment of Interveintional Radiology, Zhongshan hospital, Fudan, University, Shanghai, China.
Zhongshan Hospital · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the safety and efficacy of interventional therapy (iodine-125[ Patients and methods: From December 2018 to October 2021, 87 HCC patients with Vp4 PVTT were included in this single-center retrospective study. Forty-seven patients underwent interventional therapy combined with lenvatinib and anti-PD-1 antibody (group A), while 40 cases underwent interventional therapy combined with lenvatinib only (group B). Overall response rate (ORR), stent occlusion rates (SOR), median overall survival (OS), median progression-free survival (PFS) and median stent patency time (SPT) were compared between the 2 groups. Results: The mean intended dose (r = 10 mm; z = 0; 240 days) was 64.9 ± 1.0 Gy and 64.5 ± 1.1 Gy in group A and B, respectively ( Conclusion: This interventional therapy combined with lenvatinib and anti-PD-1 antibody is safe and effective for HCC patients with Vp4 PVTT.

Indexed as

anti-PD-1 antibodyhepatocellular carcinomaiodine-125 seed strandlenvatinibportal vein tumor thrombustransarterial chemoembolization

Identifiers

PMID36741718
PMCPMC9893110
OpenAlexW4317518397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.