Evidence map›Paper›PMID 36741507›Full record

ArticleChemical science2023

The thiol-sulfoxonium ylide photo-click reaction for bioconjugation.

Chuan Wan, Zhanfeng Hou, Dongyan Yang, Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Mingchan Liang, Jun Meng, Jiean Chen and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chuan WanState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.
Zhanfeng HouState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.
Dongyan YangCollege of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering Guangzhou 510225 P. R. China.
Ziyuan ZhouNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116 P. R. China.
Hongkun XuState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.
Yuena WangState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.
Chuan DaiState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.ORCID https://orcid.org/0000-0002-8437-4303
Mingchan LiangPingshan Translational Medicine Center, Shenzhen Bay Laboratory Shenzhen 518118 P. R. China wangrui@szbl.ac.cn yinfeng@szbl.ac.cn.
Jun MengNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116 P. R. China.
Jiean ChenPingshan Translational Medicine Center, Shenzhen Bay Laboratory Shenzhen 518118 P. R. China wangrui@szbl.ac.cn yinfeng@szbl.ac.cn.ORCID https://orcid.org/0000-0003-0703-5831
Feng YinPingshan Translational Medicine Center, Shenzhen Bay Laboratory Shenzhen 518118 P. R. China wangrui@szbl.ac.cn yinfeng@szbl.ac.cn.ORCID https://orcid.org/0000-0001-7407-9047
Rui WangPingshan Translational Medicine Center, Shenzhen Bay Laboratory Shenzhen 518118 P. R. China wangrui@szbl.ac.cn yinfeng@szbl.ac.cn.
Zigang LiState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China lizg.sz@pku.edu.cn lizg@szbl.ac.cn.ORCID https://orcid.org/0000-0002-4649-1592
Peking University · CNShenzhen Bay Laboratory · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNZhongkai University of Agriculture and Engineering · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visible-light-mediated methods were heavily studied as a useful tool for cysteine-selective bio-conjugation; however, many current methods suffer from bio-incompatible reaction conditions and slow kinetics. To address these challenges, herein, we report a transition metal-free thiol-sulfoxonium ylide photo-click reaction that enables bioconjugation under bio-compatible conditions. The reaction is highly cysteine-selective and generally finished within minutes with naturally occurring riboflavin derivatives as organic photocatalysts. The catalysts and substrates are readily accessible and bench stable and have satisfactory water solubility. As a proof-of-concept study, the reaction was smoothly applied in chemo-proteomic analysis, which provides efficient tools to explore the druggable content of the human proteome.

Identifiers

PMID36741507
PMCPMC9847666
OpenAlexW4313344966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.