Evidence map›Paper›PMID 36741385›Full record

ArticleFrontiers in immunology2022

Lysine methyltransferase Kmt2d regulates naive CD8

Jaekwan Kim, Thomas Nguyen, Jeffrey Cifello, Raheel Ahmad, Yongqing Zhang, Qian Yang, Ji-Eun Lee, Xiang Li, Yan Kai, Supriyo De and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jaekwan KimLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Thomas NguyenLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Jeffrey CifelloLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Raheel AhmadLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Yongqing ZhangLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Qian YangLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Ji-Eun LeeLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Xiang LiDepartment of Physics, George Washington University, Washington DC, WA, United States.
Yan KaiDepartment of Physics, George Washington University, Washington DC, WA, United States.
Supriyo DeLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Weiqun PengDepartment of Physics, George Washington University, Washington DC, WA, United States.
Kai GeLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Nan-Ping WengLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
National Institutes of Health · USNational Institute on Aging · USGeorge Washington University · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Molecular Mechanisms Of Memory T CellsZ01AG000757 · NIA · NATIONAL INSTITUTE ON AGING · PI WENG, NAN PING PETER · 1998 to 2008
$1.2M
Intramural NIH HHS Z01 AG000757NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874
6 · The paper itself

Abstract

Lysine specific methyltransferase 2D (Kmt2d) catalyzes the mono-methylation of histone 3 lysine 4 (H3K4me1) and plays a critical role in regulatory T cell generation

Indexed as

CD8-Positive T-LymphocytesHistone-Lysine N-MethyltransferaseLysineAnimalsBiomarkersHistonesMiceMyeloid-Lymphoid Leukemia ProteinTranscription FactorsBiomarkersHistone-Lysine N-MethyltransferaseHistonesKmt2d protein, mouseLysineMyeloid-Lymphoid Leukemia ProteinTranscription Factorscell deathH3K4me1KMT2Dnaive CD8+ T cellsproliferation

Identifiers

PMID36741385
PMCPMC9892454
OpenAlexW4317387974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.