Evidence map›Paper›PMID 36741030›Full record

ArticleJournal of psychiatry and brain science2022

The Role of Sex in Genetic Association Studies of Depression.

Karin F Hoth, Kirsten Voorhies, Ann Chen Wu, Christoph Lange, James B Potash, Sharon M Lutz

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry and brain science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Karin F HothDepartment of Psychiatry and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
Kirsten VoorhiesPrecision Medicine Translational Research Center (PROMoTeR), Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA.
Ann Chen WuPrecision Medicine Translational Research Center (PROMoTeR), Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA.
Christoph LangeDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
James B PotashDepartment Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, MD 21287, USA.
Sharon M LutzPrecision Medicine Translational Research Center (PROMoTeR), Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA.
Harvard Pilgrim Health Care · USHarvard University · USJohns Hopkins University · USUniversity of Iowa · US

Funding

The role of sex in genetic association studies of depressionR01MH129337 · NIMH · HARVARD PILGRIM HEALTH CARE, INC. · PI Sharon Marie Lutz · 2022 to 2026
$2.1M
NIMH NIH HHS R01 MH129337
6 · The paper itself

Abstract

Depression is the most common mental illness in the U.S. affecting nearly 40 million adults age 18 years and older. Depression has both genetic and environmental influences. In addition, women are more likely to be affected by depression than men. However, the relationship between genes and depression is complex and may be influenced by sex. Understanding the genetic basis of sex-specific differences for depression has the potential to lead to new biological understanding of the etiology of depression in females compared to males and to promote the development of novel and more effective pharmacotherapies. This review examines the role of sex in genetic associations with depression for both genome-wide association and candidate gene studies. While the genetic association signals of depression differ by sex, the role of sex in the heritability of depression is complex and warrants further investigation.

Indexed as

depressiongenome wide association studiessex stratifiedSNP by sex interaction

Identifiers

PMID36741030
PMCPMC9894025
OpenAlexW4313428880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.