Evidence map›Paper›PMID 36740765›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins.

Alice S Ryan, Guoyan Li

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. SIRT1 and exercise-induced bone metabolism: a regulatory nexus.Frontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alice S RyanVeterans Affairs, Division of Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, and Baltimore GRECC, Baltimore, MD 21201, USA.ORCID 0000-0003-3708-110X
Guoyan LiVeterans Affairs, Division of Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, and Baltimore GRECC, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Diet and Exercise: Race, Postmenopause and MetabolismR01AG019310 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · 2001 to 2005
$1.5M
Age, Lifestyle, Muscle Mechanisms in Insulin ResistanceK01AG021457 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSEPH, LYNDON J O · 2004 to 2007
$490k
RR&D Research Career Scientist Award ApplicationIK6RX003977 · VA · BALTIMORE VA MEDICAL CENTER · PI ALICE S. RYAN · 2022 to 2026
–
NIA NIH HHS K01 AG021457NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG019310RRD VA IK6 RX003977
6 · The paper itself

Abstract

The sirtuins, SIRT1 and SIRT3, are involved in the control of cellular processes to maintain metabolic homeostasis. The purpose of this study was to determine the effects of a 6-month aerobic training + weight loss program and hyperinsulinemia on SIRT1 and SIRT3 expression in skeletal muscle and to compare their expression between men and women. Thirty-five adult men (

Indexed as

Sirtuin 3SirtuinsAgedExerciseFemaleHumansInsulinMaleMiddle AgedMuscle, SkeletalRNA, MessengerSex CharacteristicsWeight LossInsulinRNA, MessengerSIRT3 protein, humanSirtuin 3SirtuinsExerciseglucosemetabolismnutritionobesityskeletal muscle

Identifiers

PMID36740765
PMCPMC10159525
OpenAlexW4319295002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.