Evidence map›Paper›PMID 36740584›Full record

ArticleThe Journal of infectious diseases2023

Dynamics of Anti-influenza Mucosal IgA Over a Season in a Cohort of Individuals Living or Working in a Long-term Care Facility.

Matt D T Hitchings, Brooke A Borgert, Adam Shir, Bingyi Yang, Kyra H Grantz, Jacob Ball, Carlos A Moreno, Kenneth Rand, Parker A Small, Keith R Fowke and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Matt D T HitchingsDepartment of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-2327-3557
Brooke A BorgertDepartment of Biology, University of Florida, Gainesville, Florida, USA.
Adam ShirDepartment of Biology, University of Florida, Gainesville, Florida, USA.
Bingyi YangDepartment of Biology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-0811-8332
Kyra H GrantzDepartment of Biology, University of Florida, Gainesville, Florida, USA.
Jacob BallEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Carlos A MorenoDepartment of Biology, University of Florida, Gainesville, Florida, USA.
Kenneth RandDepartment of Pathology, University of Florida, Gainesville, Florida, USA.
Parker A SmallEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Keith R FowkeDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
Derek A T CummingsDepartment of Biology, University of Florida, Gainesville, Florida, USA.
University of Florida · USJohns Hopkins University · USUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerological surveys are used to ascertain influenza infection and immunity, but evidence for the utility of mucosal immunoglobulin A (IgA) as a correlate of infection or protection is limited.

methodsWe performed influenza-like illness (ILI) surveillance on 220 individuals living or working in a retirement community in Gainesville, Florida from January to May 2018, and took pre- and postseason nasal samples of 11 individuals with polymerase chain reaction (PCR)-confirmed influenza infection and 60 randomly selected controls. Mucosal IgA against 10 strains of influenza was measured from nasal samples.

resultsOverall, 28.2% and 11.3% of individuals experienced a 2-fold and 4-fold rise, respectively, in mucosal IgA to at least 1 influenza strain. Individuals with PCR-confirmed influenza A had significantly lower levels of preseason IgA to influenza A. Influenza-associated respiratory illness was associated with a higher rise in mucosal IgA to influenza strains of the same subtype, and H3N2-associated respiratory illness was associated with a higher rise in mucosal IgA to other influenza A strains.

conclusionsBy comparing individuals with and without influenza illness, we demonstrated that mucosal IgA is a correlate of influenza infection. There was evidence for cross-reactivity in mucosal IgA across influenza A subtypes.

Indexed as

Influenza, HumanInfluenza VaccinesAntibodies, ViralHumansImmunity, MucosalImmunoglobulin AInfluenza A Virus, H3N2 SubtypeLong-Term CareNasal MucosaNursing HomesSeasonsAntibodies, ViralImmunoglobulin AInfluenza Vaccinesinfluenzamucosal immunitysurveillance

Identifiers

PMID36740584
PMCPMC10428196
OpenAlexW4319263423

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.