Evidence map›Paper›PMID 36740564›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2023

Cannabis use and post-operative complications in patients undergoing pancreatic resection.

Helen J Madsen, Heather Carmichael, Trenton Reinicke, Ana L Gleisner, Marco Del Chiaro, Richard D Schulick, Camille L Stewart

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Helen J MadsenDepartment of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA. Electronic address: Helen.madsen@CUAnschutz.edu.
Heather CarmichaelDepartment of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA.
Trenton ReinickeDepartment of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA.
Ana L GleisnerDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA; University of Colorado Cancer Center, Denver, CO, USA.
Marco Del ChiaroDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA; University of Colorado Cancer Center, Denver, CO, USA.
Richard D SchulickDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA; University of Colorado Cancer Center, Denver, CO, USA.
Camille L StewartDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, MS C-310, Room 6602, Aurora, CO 80045, USA; University of Colorado Cancer Center, Denver, CO, USA.
University of Colorado Cancer Center · USUniversity of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

backgroundMany states have legalized medical cannabis with various reported therapeutic benefits. However, there is little data assessing the effects of cannabis on surgical outcomes. We sought to compare post-operative pancreatic resection complications between cannabis users and non-users.

methodsThis is a single-center, retrospective review of patients who underwent Whipple or distal pancreatectomy from 1/2017-12/2020. The primary outcome was any in-hospital complication, using Clavien-Dindo. Multivariable regression analysis was performed.

resultsThere were 486 patients who underwent Whipple (n=346, 71.2%) or distal pancreatectomy (n=140, 28.8%). Overall, 21.4% (n=104) reported cannabis use, of whom 80.8% were current users. Cannabis users were younger (60 vs. 66 years, p < 0.001), and more likely to have smoked tobacco (p=0.04), but otherwise had similar demographics as non-users. There were 288 (59.3%) patients who developed an in-hospital complication (grade 1-2, 75.3%; grade 3-5, 24.7%). A trend towards increased complications was observed with tobacco smoking (OR 1.33, 95% CI 0.91-1.94, p=0.14), but no association of cannabis use with complications was observed (OR 0.93, 95% CI 0.58-1.47, p=0.74). DISCUSSION: A significant proportion of patients undergoing pancreatic resection report cannabis use. These results suggest that there was no association between cannabis use and post-operative complications, future prospective evaluation is warranted.

Indexed as

CannabisPancreatic NeoplasmsHumansPancreatectomyPostoperative ComplicationsRetrospective Studies

Identifiers

PMID36740564
PMCPMC12746831
OpenAlexW4319294869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.